Promising Loci and Genes for Yolk and Ovary Weight in Chickens Revealed by a Genome-Wide Association Study

PloS One
Congjiao SunNing Yang

Abstract

Because it serves as the cytoplasm of the oocyte and provides a large amount of reserves, the egg yolk has biological significance for developing embryos. The ovary and its hierarchy of follicles are the main reproductive organs responsible for yolk deposition in chickens. However, the genetic architecture underlying the yolk and ovarian follicle weights remains elusive. Here, we measured the yolk weight (YW) at 11 age points from onset of egg laying to 72 weeks of age and measured the follicle weight (FW) and ovary weight (OW) at 73 weeks as part of a comprehensive genome-wide association study (GWAS) in 1,534 F2 hens derived from reciprocal crosses between White Leghorn (WL) and Dongxiang chickens (DX). For all ages, YWs exhibited moderate single nucleotide polymorphism (SNP)-based heritability estimates (0.25-0.38), while the estimates for FW (0.16) and OW (0.20) were relatively low. Independent univariate genome-wide screens for each trait identified 12, 3, and 31 novel significant associations with YW, FW, and OW, respectively. A list of candidate genes such as ZAR1, STARD13, ACER1b, ACSBG2, and DHRS12 were identified for having a plausible function in yolk and follicle development. These genes are important to the initiat...Continue Reading

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Citations

Jul 30, 2016·Poultry Science·Weiguang XiaChuntian Zheng
Jul 20, 2016·PloS One·Manman ShenNing Yang
May 15, 2018·Frontiers in Genetics·Zhuang LiuNing Yang
Jun 27, 2019·Scientific Reports·Eirini TarsaniAntonios Kominakis
Nov 27, 2020·Frontiers in Physiology·Colin G Scanes

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Methods Mentioned

BETA
genotyping

Software Mentioned

R script
Affymetrix Power Tools
Haploview
GenABEL
R
BioMart
Ensembl
Affymetrix
GEMMA
BEAGLE

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