Promising Modalities to Identify and Monitor Eosinophilic Esophagitis

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Girish Hiremath, Sandeep K Gupta

Abstract

Eosinophilic esophagitis (EoE) is an allergen-mediated condition characterized by symptoms of esophageal dysfunction and histologic evidence of intense eosinophilic inflammation involving the esophagus in the absence of overlapping conditions such as gastroesophageal reflux disease. Since the initial description as a distinct entity approximately 2 decades ago, there has been a remarkable increase in the recognition of this clinicopathologic entity. The current approach to diagnose and monitor EoE requires repeated esophagogastroduodenoscopies, with associated sedation/anesthesia, to visualize mucosal abnormalities, and to obtain multiple biopsy specimens for histologic assessment and to evaluate treatment response. Frequent esophagogastroduodenoscopies with multiple biopsies can increase the risk of procedural complications, place significant financial burden on families, and escalate health care costs. In addition, this burdensome approach may contribute toward delayed diagnosis and suboptimal monitoring, thereby increasing the likelihood of complications such as esophageal narrowing and stricture formation, which may require escalation of care including endoscopic interventions. Clinical progression and complications associa...Continue Reading

Associated Clinical Trials

Citations

Jan 22, 2020·Pediatric Research·Sanjay KumarSandeep K Gupta
Jun 23, 2020·Expert Review of Gastroenterology & Hepatology·Aditi ReddyArvind R Murali
Feb 23, 2019·JAMA Otolaryngology-- Head & Neck Surgery·Sanjay KumarSandeep K Gupta
Apr 28, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ikuo HiranoUNKNOWN Joint Task Force on Allergy-Immunology Practice Parameters

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