Promising New Agents for Colorectal Cancer

Current Treatment Options in Oncology
Satya DasRichard M Goldberg

Abstract

Choosing the optimal treatment approach for patients with metastatic colorectal cancer (mCRC) demands that oncologists assess both clinical and genomic variables and individualize care based upon the findings. Clinically, choices depend on assessing the side of the colon in which the primary tumor originates, the sites and burden of metastatic disease, the patient's performance status, and their individual comorbidities. Genomic assessment of the tumor to discern the mutational status of genes such as RAS/RAF, HER2, and TRK, as well as assessing whether tumors have defective mismatch repair (dMMR) or high microsatellite instability (MSI-H), all factor in to potential treatment options and can determine clinical trial eligibility. Metastasectomy may be an option for patients with a low burden of disease and accessible liver- or lung-limited metastases. In some unresectable cases, systemic therapy with a FOLFOX- or FOLFIRI-based regimen with or without a biologic agent can lead to sufficient disease reduction to make a patient eligible for resection of metastatic disease. Tumor sidedness and RAS mutational status guide which biologic we add to the initial chemotherapy backbone, with patients with left-sided, RAS wild-type (WT) tu...Continue Reading

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Citations

Dec 1, 2017·Nature Reviews. Gastroenterology & Hepatology·Nina FreyMichael Bitzer
Feb 18, 2020·International Journal of Colorectal Disease·Ruth VeraCarles Pericay
Nov 30, 2018·International Journal of Molecular Sciences·Diego MontagnerCristina Marzano
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May 28, 2019·Pathology, Research and Practice·Chong LaiHonghe Zhang
Jan 14, 2022·Journal of Comparative Effectiveness Research·Chunhui JinJianliang You

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