Promising Plant-Derived Adjuvants in the Development of Coccidial Vaccines

Frontiers in Veterinary Science
Valeria A SanderMarina Clemente

Abstract

Coccidial parasites cause medical and veterinary diseases worldwide, frequently leading to severe illness and important economic losses. At present, drugs, chemotherapeutics and prophylactic vaccines are still missing for most of the coccidial infections. Moreover, the development and administration of drugs and chemotherapeutics against these diseases would not be adequate in livestock, since they may generate unacceptable residues in milk and meat that would avoid their commercialization. In this scenario, prophylactic vaccines emerge as the most suitable approach. Subunit vaccines have proven to be biologically safe and economically viable, allowing researchers to choose among the best antigens against each pathogen. However, they are generally poorly immunogenic and require the addition of adjuvant compounds to the vaccine formulation. During the last decades, research involving plant immunomodulatory compounds has become an important field of study based on their potential pharmaceutical applications. Some plant molecules such as saponins, polysaccharides, lectins and heat shock proteins are being explored as candidates for adjuvant/carriers formulations. Moreover, plant-derived immune stimulatory compounds open the possib...Continue Reading

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Citations

Jul 17, 2020·Frontiers in Cellular and Infection Microbiology·Valeria A SanderMarina Clemente
Oct 17, 2020·Frontiers in Veterinary Science·Naila ShahidAbdul Qayyum Rao
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Feb 9, 2021·Frontiers in Bioengineering and Biotechnology·Mariana G CoriglianoMarina Clemente
Jun 22, 2021·Frontiers in Pharmacology·Seyed Davoud JazayeriChit Laa Poh
Aug 14, 2021·Science·Hugues Fausther-Bovendo, Gary Kobinger
Nov 30, 2021·Journal of Agricultural and Food Chemistry·Ping S YatesBao-Hua Song

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Methods Mentioned

BETA
X-ray

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