Promising therapies for the treatment of chronic lymphocytic leukemia

Expert Opinion on Investigational Drugs
Fortunato MorabitoMassimo Gentile

Abstract

The combination schedule of fludarabine, cyclophosphamide and rituximab is the gold standard of therapy for younger, physically fit chronic lymphocytic leukemia (CLL) patients; it allows achieving high and durable complete response rates. Although treatment outcome has considerably improved with chemo-immunotherapy, most patients eventually relapse and CLL is still incurable. Thus, newer and more rationally developed drugs are needed to improve CLL therapy, particularly in cases of relapsed/refractory disease. The authors review preclinical and clinical data regarding newer CLL agents, currently undergoing examination, such as: signal transduction and cyclin-dependent kinase inhibitors, immunomodulatory agents, B-cell lymphoma 2 inhibitors, next generation mAbs, heat shock protein 90 and histone deacetylase inhibitors, and chimeric antigen receptor T-cell therapy. Newer compounds with different mechanisms of action, such as B-cell receptor signal transduction inhibitors, lenalidomide, next generation mAbs and several pro-apoptotic molecules, have shown efficacy in relapsed or refractory CLL patients. Several studies are under way to investigate the efficacy of combinations of these novel drugs. Hopefully, the combined use of th...Continue Reading

References

Jun 30, 2001·The Journal of Biological Chemistry·S H Chao, D H Price
Jun 11, 2002·Biochemical and Biophysical Research Communications·Walter Filgueira de AzevedoNelson José Freitas da Silveira
Feb 25, 2005·The New England Journal of Medicine·Nicholas ChiorazziManlio Ferrarini
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica L TeelingJan G J van de Winkel
Nov 8, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Asher Chanan-KhanMyron S Czuczman
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John C ByrdSarah Harris
Feb 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Asher A Chanan-Khan, Bruce D Cheson
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul V BeumRonald P Taylor
Oct 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas S LinJohn C Byrd
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William G WierdaUNKNOWN Hx-CD20-406 Study Investigators
Dec 30, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine I ChenSuzanne Trudel
Feb 8, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luca BolognaJosée Golay
Dec 21, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew W RobertsRod Humerickhouse
Aug 8, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kirsten FischerClemens-Martin Wendtner
Oct 13, 2012·Journal of Hematology & Oncology·Shundong CangDelong Liu
Dec 12, 2012·Current Hematologic Malignancy Reports·Chitra HosingElizabeth Shpall
Dec 28, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xavier C BadouxAlessandra Ferrajoli

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Citations

Mar 10, 2016·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Cory M VelaLeslie A Andritsos
Feb 23, 2019·Journal of Extracellular Vesicles·Kathrin GärtnerReinhard Zeidler

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