Apr 20, 2019

Promising therapies for the treatment of frontotemporal dementia clinical phenotypes: from symptomatic to disease-modifying drugs

Expert Opinion on Pharmacotherapy
Giancarlo LogroscinoFrancesco Panza

Abstract

Frontotemporal dementia (FTD) is a heterogeneous clinical entity that includes several disorders characterized by different cellular mechanisms. Distinctive clinical features in FTD include behavioral, affective, and cognitive symptoms. Unfortunately, little progress has been made over the past 20 years in terms of the development of effective disease-modifying drugs with the currently available symptomatic treatments having limited clinical utility. This article reviews the principal pharmacological intervention studies for FTD. These are predominantly randomized clinical trials and include symptomatic treatments and potential disease-modifying drugs. There is insufficient evidence on effective treatments for FTD and studies with better methodological backgrounds are needed. Most studies reporting therapeutic benefits were conducted with selective serotonin reuptake inhibitors, while anti-dementia drugs have been ineffective in FTD. Since the underlying pathology of FTD mostly consists of abnormal tau protein or TDP-43 aggregates, treatments are being developed to interfere with their aggregation process or with the clearance of these proteins. Furthermore, disease-modifying treatments remain years away as demonstrated by the ...Continue Reading

  • References148
  • Citations2

References

  • References148
  • Citations2

Citations

Mentioned in this Paper

Study
Infection Prophylaxis/Management
Clinical Trials, Randomized
Phase I/II Trial
Protein TDP-43
Pharmacologic Substance
Protein Aggregation, Pathological
Tau Proteins
Frontotemporal Dementia
Selective Serotonin Reuptake Inhibitors

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