Promising treatment outcomes of intensity-modulated radiation therapy for nasopharyngeal carcinoma patients with N0 disease according to the seventh edition of the AJCC staging system.

BMC Cancer
Ying SunJun Ma

Abstract

Intensity-modulated radiation therapy (IMRT) provides excellent locoregional control for nasopharyngeal carcinoma (NPC), and has gradually replaced two-dimensional conventional radiotherapy as the first-line radiotherapy technique. Furthermore, in the new seventh edition of the American Joint Committee on Cancer (AJCC) staging system, retropharyngeal lymph nodes were upgraded from N0 to N1 disease as a result of their negative impact on the distant metastasis-free survival (DMFS) rates of NPC. This retrospective study was conducted in order to review the treatment outcomes and patterns of failure in NPC patients with N0 disease after IMRT in order to effectively guide treatment in the future. We retrospectively reviewed data from 506 biopsy-proven nonmetastatic NPC patients. There were 191 patients with negative cervical lymph node involvement. According to the seventh edition of the American Joint Committee on Cancer (AJCC) staging system, 110 patients (21.7%) were staged with N0 disease, and 81 patients (16.0%) were reclassified with N1 disease due to the presence of RLN metastasis. All patients received IMRT as the primary treatment. In patients with negative cervical lymph node involvement, distant metastasis-free survival ...Continue Reading

References

Aug 3, 2001·International Journal of Radiation Oncology, Biology, Physics·J MaH Q Min
May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Nancy LeeKaren K Fu
Apr 16, 2003·International Journal of Radiation Oncology, Biology, Physics·Michael K M KamPeter M L Teo
May 10, 2003·International Journal of Radiation Oncology, Biology, Physics·Joseph S K AuW H Lau
Dec 14, 2004·International Journal of Radiation Oncology, Biology, Physics·Michael K M KamAnthony T C Chan
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Suzanne L WoldenMichael J Zelefsky
Jul 19, 2008·Auris, Nasus, Larynx·Yupa SumitsawanHathaikarn Tooncam
Apr 14, 2009·International Journal of Radiation Oncology, Biology, Physics·Shaojun LinJiade J Lu
Apr 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Ivan Weng-Keong ThamJoseph Tien-Seng Wee
May 5, 2009·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Gareth J WebsterRanald I Mackay
Aug 4, 2009·International Journal of Radiation Oncology, Biology, Physics·Frank C S WongStewart Y Tung
Jan 2, 2010·International Journal of Radiation Oncology, Biology, Physics·Yunsheng GaoChaosu Hu
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Charles MayoThomas E Merchant
May 11, 2010·International Journal of Radiation Oncology, Biology, Physics·Wai Tong NgAnne W M Lee

❮ Previous
Next ❯

Citations

Feb 14, 2013·Drug Design, Development and Therapy·Lu ZhangHai-Qiang Mai
Feb 14, 2021·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Xin-Bin PanXiao-Dong Zhu
Dec 8, 2020·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Ji-Jin YaoYing Sun
Nov 2, 2021·Frontiers in Oncology·Jia-Lin MaXin-Bin Pan

❮ Previous
Next ❯

Methods Mentioned

BETA
prophylactic

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.