Promomycin, a polyether promoting antibiotic production in Streptomyces spp

The Journal of Antibiotics
Sho-Ichi AmanoKenji Ueda

Abstract

Widespread interspecific stimulation of antibiotic production occurs in strains of Streptomyces owing to the activity of diffusible substances, as previously determined in our investigations of the cross-feeding effect. In this study, we newly isolated a substance produced by a Streptomyces strain closely related to Streptomyces scabrisporus, based on the observation that this substance induced the production of an unknown antibiotic in another strain related to Streptomyces griseorubiginosus. This substance, named promomycin, is a polyether structurally related to lonomycin. Promomycin itself had an antibiotic activity, but it stimulated antibiotic production in multiple Streptomyces strains at sub-inhibitory concentrations. Evidence implies that this stimulation effect is widespread within this group of bacteria.

References

Jan 1, 1976·The Journal of Antibiotics·Satoshi OmuraJ Sawada
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Feb 8, 2007·Bioscience, Biotechnology, and Biochemistry·Sueharu Horinouchi
Mar 16, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Grace YimJulian Davies

Citations

Jul 28, 2011·The Journal of Antibiotics·Sho-Ichi AmanoKenji Ueda
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Weishan WangKeqian Yang
Sep 27, 2015·Journal of Industrial Microbiology & Biotechnology·Hideaki TakanoKenji Ueda
Jun 12, 2016·FEMS Microbiology Reviews·Guoqing NiuHuarong Tan
Oct 21, 2016·The Journal of Antibiotics·Kenji Ueda, Teruhiko Beppu
Sep 1, 2016·FEMS Microbiology Reviews·Bethany K Okada, Mohammad R Seyedsayamdost
Jun 1, 2017·Natural Product Reports·Navid AdnaniTim S Bugni
Jan 27, 2018·Antonie van Leeuwenhoek·Misaki IshizukaTakeshi Hosaka
Mar 31, 2015·Applied and Environmental Microbiology·Yu ImaiTakeshi Hosaka
Jan 11, 2020·Frontiers in Microbiology·Dekun KongGuoqing Niu
Apr 30, 2017·Genome Announcements·Melissa Vazquez-HernandezSergio Sánchez
Apr 11, 2019·Scientific Reports·Suresh PantheeHiroyuki Osada

Related Concepts

Interference, Bacterial
Antibiotics
Streptomyces
Lonomycin
Polyether Sulfone
Streptomyces griseorubiginosus
Enterobacteriaceae sp.
Streptomyces scabrisporus
Study

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