Promoter architectures and developmental gene regulation.

Seminars in Cell & Developmental Biology
Vanja Haberle, Boris Lenhard

Abstract

Core promoters are minimal regions sufficient to direct accurate initiation of transcription and are crucial for regulation of gene expression. They are highly diverse in terms of associated core promoter motifs, underlying sequence composition and patterns of transcription initiation. Distinctive features of promoters are also seen at the chromatin level, including nucleosome positioning patterns and presence of specific histone modifications. Recent advances in identifying and characterizing promoters using next-generation sequencing-based technologies have provided the basis for their classification into functional groups and have shed light on their modes of regulation, with important implications for transcriptional regulation in development. This review discusses the methodology and the results of genome-wide studies that provided insight into the diversity of RNA polymerase II promoter architectures in vertebrates and other Metazoa, and the association of these architectures with distinct modes of regulation in embryonic development and differentiation.

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Jan 25, 2017·Viruses·Graziele Pereira OliveiraJônatas Santos Abrahão
Feb 9, 2017·Nature Biotechnology·Nevena Cvetesic, Boris Lenhard
Jan 25, 2017·Evolution & Development·César Arenas-Mena
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Feb 28, 2020·Nature Communications·Agata OrubaDominic van Essen
Oct 24, 2020·Genome Research·Jacques SerizayJulie Ahringer
May 30, 2021·Nature Communications·Elisa OberbeckmannSebastian Eustermann
Aug 8, 2021·International Journal of Molecular Sciences·Toby Barnes, Philipp Korber

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