Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice

Carcinogenesis
P PazosAlfredo Molinolo

Abstract

The promoter effect of medroxyprogesterone acetate (MPA) on mammary carcinogenesis in female BALB/c mice was investigated using methylnitrosourea (MNU) as initiator. Nine out of 43 animals developed mammary carcinomas in the group treated with MNU (50 mg/kg) and MPA (administration of 40 mg every 3 months) starting 1 week after MNU administration. No tumors appeared in controls receiving only MNU or MPA during the time course of the experiment (9 months). The tumors were lobular adenocarcinomas showing different degrees of squamous differentiation with low or undetectable estrogen and progesterone receptors, and expressing epidermal growth factor receptors. These results support the hypothesis that MPA promotes the growth of MNU induced lesions.

Citations

Aug 16, 2008·Journal of Mammary Gland Biology and Neoplasia·D Craig Allred, Daniel Medina
May 5, 2005·Journal of the National Cancer Institute·Diane PalmieriPatricia S Steeg
Sep 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yixue CaoMichael Karin
Apr 20, 2004·Journal of Cellular Physiology·Stella Maris VázquezIsabel Alicia Lüthy
Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lourdes ArruvitoLeonardo Fainboim

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