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Promoter-enhancer interactions identified from Hi-C data using probabilistic models and hierarchical topological domains

Nature Communications

Dec 21, 2017

Gil RonTommy Kaplan

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Abstract

Proximity-ligation methods such as Hi-C allow us to map physical DNA-DNA interactions along the genome, and reveal its organization into topologically associating domains (TADs). As the Hi-C data accumulate, computational methods were developed for identifying domain borders in multiple...read more

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  • Promoter-enhancer interactions identified from Hi-C data using probabilistic models and hierarchical topological domains

    Nature Communications

    Dec 21, 2017

    Gil RonTommy Kaplan

    PMID: 29269730

    DOI: 10.1038/s41467-017-02386-3

    Abstract

    Proximity-ligation methods such as Hi-C allow us to map physical DNA-DNA interactions along the genome, and reveal its organization into topologically associating domains (TADs). As the Hi-C data accumulate, computational methods were developed for identifying domain borders in multiple...read more

    61
    168
    Paper Details
    References
    • References68
    • Citations2
    • References68
    • Citations2
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