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Promoter-enhancer interactions identified from Hi-C data using probabilistic models and hierarchical topological domains

Nature Communications

Dec 23, 2017

Gil RonTommy Kaplan

Abstract

Proximity-ligation methods such as Hi-C allow us to map physical DNA-DNA interactions along the genome, and reveal its organization into topologically associating domains (TADs). As the Hi-C data accumulate, computational methods were developed for identifying domain borders in multiple...read more

Mentioned in this Paper

Hic1
DNA-Protein Interaction
Genome
Candidate Disease Gene
Promoter
Chromatin Immunoprecipitation
Cellular Component Organization
His-His-His-His-His-His
Cell Type
Local
62
162
Paper Details
References
  • References68
  • Citations2
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Promoter-enhancer interactions identified from Hi-C data using probabilistic models and hierarchical topological domains

Nature Communications

Dec 23, 2017

Gil RonTommy Kaplan

PMID: 29269730

DOI: 10.1038/s41467-017-02386-3

Abstract

Proximity-ligation methods such as Hi-C allow us to map physical DNA-DNA interactions along the genome, and reveal its organization into topologically associating domains (TADs). As the Hi-C data accumulate, computational methods were developed for identifying domain borders in multiple...read more

Mentioned in this Paper

Hic1
DNA-Protein Interaction
Genome
Candidate Disease Gene
Promoter
Chromatin Immunoprecipitation
Cellular Component Organization
His-His-His-His-His-His
Cell Type
Local
62
162

Similar Papers Found In These Feeds

General Biology Journal eTOCs

Discover the latest general biology research in this collection of the top biology journals.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

Nature Communications

Constructing 3D interaction maps from 1D epigenomes

Nature CommunicationsMarch 11, 2016
Yun ZhuWei Wang
Paper Details
References
  • References68
  • Citations2
12345...
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