Promoter hypermethylation patterns of P16, DAPK and MGMT in oral squamous cell carcinoma: a systematic review and meta-analysis

Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research
K R DonAnuja Natesan

Abstract

Oral squamous cell carcinoma (OSCC) is a common cancer world-wide that is highly lethal due to its recurrence and metastasis. Methylation is a common epigenetic mechanism that leads to gene silencing in tumors and could be a useful biomarker in OSCC. The prevalence of P16, death-associated protein kinase (DAPK) and O6-methylguanine-DNA-methyltransferase (MGMT) promoter hypermethylation in OSCC has been evaluated for several years while the results remain controversial. The aim of this systematic review is to critically analyze and perform a meta-analysis on the various studies in the literature that have reported the promoter hypermethylation of P16, DAPK and MGMT genes in OSCC. Articles were searched and selected through PubMed. Hand search from the relevant journals was also performed. Articles were reviewed and analyzed. The estimated prevalence of P16 methylation was 43%, DAPK methylation was 39.7% and MGMT methylation was 39.8%. Heterogeneity in methylation prevalences and correlations with the clinical outcomes of the disease prevailed in various studies. We can conclude from our systematic review that a higher prevalence of methylation of P16, DAPK and MGMT occur in OSCC. Further studies are required to substantiate the ...Continue Reading

Citations

May 19, 2017·Journal of Cellular Physiology·Bharath K VelmuruganYing-Chin Ko
Jun 24, 2017·Journal of Cellular Biochemistry·Wei WangXiang-Yu Sun
Nov 13, 2019·Biochemical Genetics·Jadwiga GaździckaZofia Ostrowska
Aug 14, 2018·Pathology Oncology Research : POR·Ana Carolina de CarvalhoAndré Lopes Carvalho
Sep 15, 2017·Genetic Testing and Molecular Biomarkers·Chia-Min ChungYing-Chin Ko
Feb 13, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Garrett L JensenSameer G Jhavar

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