Promoter methylation of tumor-related genes as a potential biomarker using blood samples for gastric cancer detection

Oncotarget
Jinfeng WenGuoliang Ye

Abstract

Gene promoter methylation has been reported in gastric cancer (GC). However, the potential applications of blood-based gene promoter methylation as a noninvasive biomarker for GC detection remain to be evaluated. Hence, we performed this analysis to determine whether promoter methylation of 11 tumor-related genes could become a promising biomarker in blood samples in GC. We found that the cyclin-dependent kinase inhibitor 2A (p16), E-cadherin (CDH1), runt-related transcription factor 3 (RUNX3), human mutL homolog 1 (MLH1), RAS association domain family protein 1A (RASSF1A), cyclin-dependent kinase inhibitor 2B (p15), adenomatous polyposis coli (APC), Glutathione S-transferase P1 (GSTP1), TP53 dependent G2 arrest mediator candidate (Reprimo), and O6-methylguanine-DNAmethyl-transferase (MGMT) promoter methylation was notably higher in blood samples of patients with GC compared with non-tumor controls. While death-associated protein kinase (DAPK) promoter methylation was not correlated with GC. Further analyses demonstrated that RUNX3, RASSF1A and Reprimo promoter methylation had a good diagnostic capacity in blood samples of GC versus non-tumor controls (RUNX3: sensitivity = 63.2% and specificity = 97.5%, RASSF1A: sensitivity = 6...Continue Reading

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Citations

Jun 27, 2018·International Journal of Molecular Sciences·Julio D AmigoAlejandro H Corvalán
Jul 19, 2018·World Journal of Gastroenterology : WJG·Tasuku Matsuoka, Masakazu Yashiro
Aug 31, 2019·Journal of Oncology·Giedrius SteponaitisDaina Skiriutė
Dec 17, 2020·International Journal of Molecular Sciences·María Alejandra AlarcónAlejandro H Corvalán

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Methods Mentioned

BETA
PCR

Software Mentioned

Stata
GLOBOCAN

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