Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma.

Chinese Journal of Cancer
Ji-Sheng LiLi-Li Li

Abstract

Esophageal squamous cell carcinoma (ESCC) is a prevalent and fatal cancer in China and other Asian countries. Epigenetic silencing of key tumor suppressor genes (TSGs) is critical to ESCC initiation and progression. Recently, many novel TSGs silenced by promoter methylation have been identified in ESCC, and these genes further serve as potential tumor markers for high-risk group stratification, early detection, and prognosis prediction. This review summarizes recent discoveries on aberrant promoter methylation of TSGs in ESCC, providing better understanding of the role of disrupted epigenetic regulation in tumorigenesis and insight into diagnostic and prognostic biomarkers for this malignancy.

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Citations

Mar 27, 2013·General Thoracic and Cardiovascular Surgery·Yasushi TohManabu Yamamoto
Jun 9, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Chenchen YangXiaomei Lu
Nov 13, 2014·Clinical and Translational Science·Aparna KailasamDevendra K Agrawal
Sep 14, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaoyan XuanPingping Liu
Mar 16, 2018·International Journal of Molecular Sciences·David VranaPavel Soucek
Mar 1, 2017·International Journal of Environmental Research and Public Health·Jin HuangYuan-Shan Zhu
Aug 1, 2021·Experimental Cell Research·Reihaneh Alsadat MahmoudianMohammad Reza Abbaszadegan

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Methods Mentioned

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