Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimer's disease

Biochemical and Biophysical Research Communications
Hidehisa YamagataIkuko Kondo

Abstract

Fibroblast growth factor 1 (FGF1, also known as acidic FGF) protects selective neuronal populations against neurotoxic effects such as those in Alzheimer's disease (AD) and HIV encephalitis. The FGF1 gene is therefore a strong candidate gene for AD. Using the promoter polymorphism of the FGF1 gene, we examined the relationship between AD and the FGF1 and apolipoprotein E (APOE) genes in 100 Japanese autopsy-confirmed late-onset AD patients and 106 age-matched non-demented controls. The promoter polymorphism (-1385 A/G) was significantly associated with AD risk. The odds ratio for AD associated with the GG vs non-GG genotype was 2.02 (95% CI = 1.16-3.52), while that of s4 vs non-ł4 in APOE4 gene was 5.19 (95% CI = 2.68-10.1). The odds ratio for APOEP4 and FGF1 GG carriers was 20.5 (95% CI = 6.88-60.9). The results showed that the FGF1 gene is associated with autopsy-confirmed AD.

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Citations

Mar 27, 2010·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Hidehisa Yamagata
Apr 2, 2014·Neurobiology of Aging·Joanna L RichensPaul O'Shea
Jan 19, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Farhad MashayekhiMohammad Naji
May 1, 2009·Journal of Fish Biology·S-W ChongY-J Jiang
Apr 22, 2014·Molecular Metabolism·Alexei Kharitonenkov, Andrew C Adams
Jun 22, 2016·Placenta·Ben Ali Gannoun MarwaTouhami Mahjoub
Jun 29, 2010·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Sabrina ZechelOliver von Bohlen und Halbach
Jan 28, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Qing-Qing TaoZhi-Ying Wu
Aug 21, 2019·Cells·Pedro J Puentes-RozoJorge I Vélez
Feb 27, 2018·Brain Research Bulletin·Shusaku Uchida, Gleb P Shumyatsky
Nov 4, 2021·Molecular Biology Reports·Ramy AlamSanaa Nabha

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