Promoter polymorphism of transforming growth factor-beta1 gene and ulcerative colitis

World Journal of Gastroenterology : WJG
B TamizifarA Ghaderi

Abstract

To elucidate the possible difference in two promoter polymorphisms of the transforming growth factor-beta1 (TGF-beta1) gene (-800G > A, -509C > T) between ulcerative colitis (UC) patients and normal subjects. A total of 155 patients with established ulcerative colitis and 139 normal subjects were selected as controls. Two single nucleotide polymorphisms within the promoter region of TGF-beta1 gene (-509C > T and -800G > A) were genotyped using PCR-RFLP. There was a statistically significant difference in genotype and allele frequency distributions between UC patients and controls for the -800G > A polymorphism of the TGF-beta1 gene (P < 0.05). The frequency of the TGF-beta1 gene polymorphism at position -800 showed that the AA genotype and the allele A frequencies significantly differed between the patients and healthy controls (P < 0.05). At position -509, there was no statically significant difference in genotype and allele frequency between the patients and control subjects. The results of our study indicate that there is a significant difference in both allele and genotype frequency at position -800G > A of TGF-beta1 gene promoter between Iranian patients with UC and normal subjects.

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Citations

Jan 1, 2014·World Journal of Gastroenterology : WJG·Kamran B LankaraniShima Hassanpour
Oct 29, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Roli SaxenaJyotdeep Kaur
Mar 15, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Shin KashimaYutaka Kohgo
Jun 5, 2020·Journal of Food Biochemistry·Denisse Aurora Díaz-CoronaMisael Odín Vega-García
Dec 3, 2020·Clinical, Cosmetic and Investigational Dermatology·Bryar T AhmedDashty M Amin

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