Promoter polymorphisms of the vascular endothelial growth factor gene are associated with metabolic syndrome susceptibility in Koreans

Biomedical Reports
Young Ree Kim, Seung Ho Hong

Abstract

Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis. Patients with metabolic syndrome (MetS) have elevated plasma VEGF levels. The aim of the present study was to investigate the association between promoter polymorphisms (the -2578C>A and -1154G>A) of the VEGF gene and MetS susceptibility. A total of 640 subjects were enrolled in the study including 320 patients with MetS and 320 healthy controls. Genotyping of the VEGF single nucleotide polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism analysis. The CA and AA genotypes of the -2578C>A polymorphism were associated with decreased risk of MetS (P=0.018, P=0.003, respectively). For the -1154G>A polymorphism, although the GA genotype was more significantly frequent in MetS patients (P=0.022), the AA genotype and recessive model (GG+GA vs. AA) were protective against MetS susceptibility (P=0.016, 0.007, respectively). The A-G haplotype frequency composed of the -2578C>A and -1154G>A polymorphisms also differed between the 2 groups (P=0.011). The presented data suggested that the A alleles and A-G haplotype of the VEGF -2578C>A and -1154G>A polymorphisms are associated with decreased MetS susceptibility. To ...Continue Reading

References

Apr 24, 1999·Journal of Vascular Research·W Renner, E Pilger
Feb 28, 2001·Reproduction : the Official Journal of the Society for the Study of Fertility·C E Gargett, P A Rogers
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Peter KripplHellmut Samonigg
Nov 16, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Michael I KoukourakisEfthimios Siviridis
Apr 12, 2005·Fertility and Sterility·Dimitrios PapazoglouGeorgios B Maroulis
Jun 7, 2005·Journal of Medical Genetics·W M HowellS Ye
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lukas A HeflerRobert Zeillinger
Sep 25, 2007·Breast Cancer Research and Treatment·Bryan P SchneiderDavid A Flockhart
Oct 3, 2008·International Journal of Colorectal Disease·Paolo MalteseMauro Magnani
Jul 24, 2010·Journal of Internal Medicine·M SiervoM Ciullo
Sep 10, 2011·American Journal of Reproductive Immunology : AJRI·Young Joo JeonNam Keun Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.