Promoter structure of the MxA gene that confers resistance to influenza virus

FEBS Letters
K NakadeK Nagata

Abstract

The human MxA protein is one of the interferon-inducible proteins that inhibits multiplication of influenza virus and other viruses. To clarify the control mechanism of its expression, we prepared a series of mutant MxA promoters and identified a 30 nucleotides long cis-acting interferon-responsive element by transient transfection assay. Its nucleotide sequence is somewhat similar to that of ISRE (interferon-stimulated response element), suggesting that the regulation of MxA mRNA synthesis is under the control of some ISRE binding factor such as ISGF-3 (interferon-stimulated gene factor-3).

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Citations

Jan 27, 2004·Biochemical and Biophysical Research Communications·Shen-Long HowngYi-Ren Hong
Dec 31, 2003·Developmental and Comparative Immunology·Stephen M AltmannCarol H Kim
Sep 24, 2013·Fish & Shellfish Immunology·Daniel Alvarez-TorresEsther Garcia-Rosado
Jul 2, 2008·Parkinsonism & Related Disorders·N KawaguchiT Hattori
Feb 11, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kohji YamadaTomomasa Watanabe
Mar 15, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Shinichi HayashiShu Hashimoto
Jan 23, 1999·Immunological Reviews·J C LeongB Simon
Feb 8, 2008·Animal Genetics·P TungtrakoolsubT Watanabe
Apr 14, 2015·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Noha Gamal Bader El DinMostafa K El Awady
Aug 7, 2007·Cytogenetic and Genome Research·T Watanabe
Dec 3, 2014·Experimental Cell Research·Carlos Eduardo Brantis-de-CarvalhoSandro Roberto Valentini

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