PMID: 15223866Jun 30, 2004Paper

Promoter variants in tissue inhibitor of metalloproteinase-3 (TIMP-3) protect against susceptibility in pigeon breeders' disease

Thorax
M R HillA Pardo

Abstract

Tissue inhibitors of metalloproteinases (TIMPs) play a major role in extracellular matrix turnover in the lung. However, in chronic lung disorders such as idiopathic pulmonary fibrosis (IPF) and pigeon breeders' disease (PBD), TIMPs may promote an adverse non-degradative environment. We hypothesised that polymorphisms in TIMP-3 could affect susceptibility to IPF and PBD. Two promoter variants, -915A>G and -1296T>C, were genotyped in 323 healthy subjects, 94 subjects with IPF, 115 with PBD, and 90 exposed to avian antigen but without PBD. The severity of fibrosis in lung tissue and the clinical outcome after 1 year was determined in the PBD group. The variants did not influence susceptibility to IPF, but the rare alleles of both variants appeared to be protective against susceptibility to PBD (odds ratio (OR) for carriage of at least one rare allele from either variant 0.48, 95% CI 0.30 to 0.76, p = 0.002). Haplotype analysis of positions -915 and -1296 estimated four haplotypes: *A*T, *G*T, *A*C and *G*C, respectively. Their frequencies differed overall between subjects with PBD and healthy subjects (p = 0.0049) and this was attributable primarily to the *G*C haplotype (OR 0.53, 95% CI 0.36 to 0.77, p = 0.001). The severity of ...Continue Reading

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Citations

Aug 27, 2011·Clinical Reviews in Allergy & Immunology·Andrew L ChanTimothy E Albertson
Apr 14, 2007·American Journal of Respiratory and Critical Care Medicine·Martha L BustosMoisés Selman
Jun 9, 2012·American Journal of Respiratory and Critical Care Medicine·Moisés SelmanTalmadge E King
Oct 30, 2012·Immunology and Allergy Clinics of North America·Shinichiro OhshimoUlrich Costabel
Mar 1, 2012·Clinics in Chest Medicine·Ulrich CostabelJosune Guzman
Apr 28, 2016·Expert Review of Clinical Immunology·Yasunari MiyazakiNaohiko Inase
Nov 24, 2006·Journal of Dental Research·J Verstappen, J W Von den Hoff
Nov 15, 2007·Reproductive Sciences·Julia V CockleNicolas M Orsi
Jun 1, 2019·American Journal of Respiratory and Critical Care Medicine·Martina VasakovaGanesh Raghu
Jan 16, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jin WangElizabeth A Fitzpatrick
Jul 25, 2020·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuKevin C Wilson
Aug 9, 2020·Nature Reviews. Disease Primers·Ulrich CostabelMoises Selman
Feb 16, 2019·Translational Research : the Journal of Laboratory and Clinical Medicine·Susan K Mathai, David A Schwartz
Feb 7, 2008·Archives of Pathology & Laboratory Medicine·Bruce A Woda

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