Promoter Variation and Gene Expression of mcr-1 -Harboring Plasmids in Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from a Chinese Hospital

Antimicrobial Agents and Chemotherapy
Bin HuangLiang Chen

Abstract

Next-generation sequencing of 6 mcr-1-harboring Escherichia coli and Klebsiella pneumoniae isolates collected from a tertiary care hospital in China revealed significant sequence variations in the regions flanking the mcr-1 gene. While sequence variations significantly affected the expression and promoter activity of mcr-1, the mcr-1 gene expression levels did not correlate with the in vitro colistin resistance levels, which warrants further in-depth investigations.

References

Jan 13, 2012·Journal of Clinical Microbiology·Mette V LarsenOle Lund
Jul 12, 2012·The Journal of Antimicrobial Chemotherapy·Ea ZankariMette Voldby Larsen
May 11, 2016·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
Jun 28, 2016·The Journal of Antimicrobial Chemotherapy·Stefan Schwarz, Alan P Johnson
Feb 9, 2017·Antimicrobial Agents and Chemotherapy·Brandon EilertsonBarry N Kreiswirth

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Citations

May 18, 2020·The Journal of Antimicrobial Chemotherapy·Xiaoming WangZhangqi Shen
Oct 13, 2020·Critical Reviews in Microbiology·Shi XiaominWang Shaolin
Jun 4, 2021·International Journal of Antimicrobial Agents·Shang LuFan Yang
Nov 13, 2021·Frontiers in Cellular and Infection Microbiology·Yanling LiuLingbing Zeng

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