Promoting Acute Thrombolysis for Ischaemic Stroke (PRACTISE)

International Journal of Stroke : Official Journal of the International Stroke Society
Maaike DirksPromoting Acute Thrombolysis for Ischaemic Stroke (PRACTISE)

Abstract

Thrombolysis with intravenous rtPA is an effective treatment for patients with ischaemic stroke if given within 3 h from onset. Generally, more than 20% of stroke patients arrive in time to be treated with thrombolysis. Nevertheless, in most hospitals, only 1-8% of all stroke patients are actually treated. Interorganisational, intraorganisational, medical and psychological barriers are hampering broad implementation of thrombolysis for acute ischaemic stroke. To evaluate the effect of a high-intensity implementation strategy for intravenous thrombolysis in acute ischaemic stroke, compared with regular implementation; to identify success factors and obstacles for implementation and to assess its cost-effectiveness, taking into account the costs of implementation. The PRACTISE study is a national cluster-randomised-controlled trial. Twelve hospitals have been assigned to the regular or high-intensity intervention by random allocation after pair-wise matching. The high-intensity implementation consists of training sessions in conformity with the Breakthrough model, and a tool kit. All patients who are admitted with acute stroke and onset of symptoms not longer than 24 h are registered. The primary outcome measure is treatment with...Continue Reading

References

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Citations

May 27, 2011·QJM : Monthly Journal of the Association of Physicians·J D H van WijngaardenD W J Dippel
Jan 23, 2009·BMC Health Services Research·Assunta De LucaUNKNOWN IMPLementazione Percorso Clinico Assistenziale ICtus Acuto (IMPLICA) Study Group
Dec 16, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Maaike DirksUNKNOWN PRACTISE investigators
Dec 31, 2014·Acta Neuropathologica·Isabel Perez-de-PuigAnna M Planas
Aug 12, 2009·Nature Reviews. Neurology·Miriam BouckaertVincent Thijs
Jul 30, 2014·The Cochrane Database of Systematic Reviews·Joanna M WardlawGregory J del Zoppo
Jul 28, 2013·Stroke; a Journal of Cerebral Circulation·Inger de RidderUNKNOWN PRACTISE Investigators
Mar 12, 2011·Stroke; a Journal of Cerebral Circulation·Maaike DirksUNKNOWN PRomoting ACute Thrombolysis in Ischemic StrokE (PRACTISE) Investigators
Apr 17, 2010·Stroke; a Journal of Cerebral Circulation·Marie ErikssonUNKNOWN Riks-Stroke Collaboration
Sep 12, 2021·Scientific Reports·Abbas MoghanizadehAntoine Ferreira

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Methods Mentioned

BETA
percutaneous
coronary

Software Mentioned

PRACTISE

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