PMID: 11933043Apr 5, 2002Paper

Promoting axonal regeneration in the central nervous system by enhancing the cell body response to axotomy

Journal of Neuroscience Research
Ward PlunetWolfram Tetzlaff

Abstract

Neurons projecting into the peripheral nervous system (PNS) regenerate their axons after injury, in contrast to those confined to the central nervous system (CNS). Both neuronal and nonneuronal factors contribute to the lack of CNS regeneration. In this review we concentrate on the differential gene expression response to axotomy in PNS vs. CNS neurons. In general CNS neurons fail to up-regulate or sustain the expression of regeneration-associated proteins (RAGs), including trophic factors and their receptors. The presumed lack of trophic support of axotomized CNS neurons provided the rationale for the exogenous application of trophic factors, either to the lesion site or to the cell bodies. Here, we review our data on the application of trophic factors to rubrospinal and corticospinal neurons. Cell body treatment of axotomized rubrospinal neurons with brain-derived neurotrophic factor (BDNF) reversed atrophy, increased GAP-43 and Talpha-1 tubulin mRNA expression, and promoted axonal regeneration into peripheral nerve grafts. Importantly, BDNF cell body treatment was still effective in the chronic setting, i.e., when initiated 1 year after injury, but BDNF had no effect when applied to the chronic spinal cord injury site. The a...Continue Reading

References

Jan 1, 1989·Annual Review of Neuroscience·J H Skene
Feb 1, 1984·Journal of Neurocytology·P M RichardsonA J Aguayo
Mar 20, 1980·Nature·P M RichardsonA J Aguayo
Jan 1, 1994·Progress in Brain Research·W TetzlaffA M Bedard
Feb 24, 1994·Neuroreport·F PiehlS Cullheim
May 1, 1996·The European Journal of Neuroscience·N R KobayashiW Tetzlaff
Jun 1, 1996·The European Journal of Neuroscience·K M Giehl, W Tetzlaff
Sep 14, 1999·Brain Research Bulletin·J W Fawcett, R A Asher
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·L I BenowitzN Irwin
Jun 9, 2000·Annual Review of Neuroscience·J L Goldberg, B A Barres
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·F E HolmesD Wynick
Feb 13, 2001·Experimental Neurology·D J LieblL F Parada
Feb 13, 2001·Journal of Neuroscience Research·J McGrawJ D Steeves
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·F S Lee, M V Chao
May 15, 2001·The Journal of Physiology·L L JonesM H Tuszynski

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Citations

Mar 31, 2005·Molecular and Cellular Neurosciences·Przemyslaw S SapiehaAdriana Di Polo
Jun 7, 2005·Molecular and Cellular Neurosciences·Sylvain NadeauFreda D Miller
Dec 23, 2003·Progress in Neurobiology·Joris de Wit, Joost Verhaagen
Nov 1, 2003·Medical Hypotheses·M ben-Aaron
Oct 1, 2003·Clinical and Experimental Pharmacology & Physiology·Lisa N Gillespie
Nov 8, 2008·Molekuliarnaia biologiia·E N Kozlova
Jan 30, 2004·Annual Review of Medicine·Bruce H Dobkin, Leif A Havton
May 21, 2003·BMC Neuroscience·Andreas B SchmittFranz-Werner Schwaiger
Oct 27, 2009·Journal of Brachial Plexus and Peripheral Nerve Injury·Qiuju YuanWutian Wu
Jun 6, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Derya AyazBassem A Hassan
May 17, 2008·Upsala Journal of Medical Sciences·Leif AnderbergAnders Holtz
Feb 21, 2009·Neurosurgical Focus·Tessa Gordon
May 7, 2014·Marine Drugs·Clara GrossoPaula B Andrade
Jan 20, 2010·Journal of Neuropathology and Experimental Neurology·Neil G HarrisRichard L Sutton
Jan 22, 2011·Neuropharmacology·Jamie R FlynnRobert J Callister
Feb 4, 2010·Molecular and Cellular Neurosciences·Matthew B VeldmanDaniel Goldman
Jul 1, 2008·Experimental Neurology·Ward T PlunetWolfram Tetzlaff
Mar 1, 2008·Neuroscience Letters·Loren W OschipokWolfram Tetzlaff
Oct 9, 2007·Experimental Neurology·Peter AhlbornAndrey Irintchev
Apr 1, 2008·Materials Science & Engineering. C, Materials for Biological Applications·Jessica O WinterJoseph F Rizzo
Dec 22, 2005·The European Journal of Neuroscience·Philip J HarveyDavid J Bennett
Dec 13, 2005·Journal of Neurochemistry·Xing-Yun SongXin-Fu Zhou
May 8, 2007·The FEBS Journal·Guennadi KozlovKalle Gehring
Feb 22, 2011·Journal of Neuroscience Research·Chung-Ren LinKuan-Hung Chen
Jul 16, 2010·Annals of the New York Academy of Sciences·Ward T PlunetWolfram Tetzlaff
May 23, 2014·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Ilaria CaronPietro Veglianese
Apr 27, 2005·Brain Research. Brain Research Reviews·Wolfgang J Streit
May 14, 2004·Journal of the Neurological Sciences·Kevin D Barron
May 23, 2006·Molecular and Cellular Neurosciences·Rhona SeijffersClifford J Woolf

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