Promoting axonal rewiring to improve outcome after stroke.

Neurobiology of Disease
Larry I Benowitz, S Thomas Carmichael

Abstract

A limited amount of functional recovery commonly occurs in the weeks and months after stroke, and a number of studies show that such recovery is associated with changes in the brain's functional organization. Measures that augment this reorganization in a safe and effective way may therefore help improve outcome in stroke patients. Here we review some of the evidence for functional and anatomical reorganization under normal physiological conditions, along with strategies that augment these processes and improve outcome after brain injury in animal models. These strategies include counteracting inhibitors of axon growth associated with myelin, activating neurons' intrinsic growth state, enhancing physiological activity, and having behavioral therapy. These approaches represent a marked departure from the recent focus on neuroprotection and may provide a more effective way to improve outcome after stroke.

References

Jun 1, 1990·Brain Research. Molecular Brain Research·L I BenowitzR L Neve
Sep 1, 1989·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·W Czarnecki, A Czarnecki
Jan 1, 1989·Annual Review of Neuroscience·J H Skene
Nov 1, 1995·Stroke; a Journal of Cerebral Circulation·R P StroemerC E Hulsebosch
Nov 15, 1996·Science·L C Katz, C J Shatz
Feb 1, 1997·Trends in Neurosciences·L I Benowitz, A Routtenberg
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·N WeidnerM H Tuszynski
Oct 11, 2001·Neurobiology of Disease·S T CarmichaelT A Woolsey
Apr 12, 2002·Nature·Elizabeth J BradburyStephen B McMahon
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lisa McKerracher
Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Peng ChenLarry I Benowitz
Oct 12, 2002·Proceedings of the National Academy of Sciences of the United States of America·Heidi Johansen-BergPaul M Matthews
Nov 9, 2002·Science·Tommaso PizzorussoLamberto Maffei
Nov 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gwen S ScottD Craig Hooper
Sep 3, 2003·Nature Reviews. Neuroscience·Marie T Filbin
Jan 22, 2004·Nature Reviews. Neuroscience·Jerry Silver, Jared H Miller
Jan 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeffrey A KleimMichael Remple
Jan 30, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Helen M Bramlett, W Dalton Dietrich
Mar 3, 2004·Annals of Neurology·Nagako MuraseLeonardo G Cohen
Mar 17, 2004·Trends in Pharmacological Sciences·György HaskóCsaba Szabó
May 28, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeffrey L GoldbergBen A Barres
Jul 9, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jung-Kil LeeStephen M Strittmatter
Jul 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul LuMark H Tuszynski
Oct 8, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dietmar FischerLarry I Benowitz
Jan 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karthik VenkateshRoman J Giger
Feb 5, 2005·Stroke; a Journal of Cerebral Circulation·Hui ShenYun Wang
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Gwen S ScottD Craig Hooper
Mar 5, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·John H Martin
Jul 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·M Douglas BensonLuis F Parada
Aug 13, 2005·Experimental Brain Research·Steven C Cramer, Kit R Crafton
Oct 1, 2005·Science·Aaron W McGeeStephen M Strittmatter
Nov 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Numa DancauseRandolph J Nudo
Apr 25, 2006·Annals of Neurology·S Thomas Carmichael

❮ Previous
Next ❯

Citations

Nov 26, 2010·Nature Neuroscience·Martin E Schwab
Jan 19, 2011·Nature Reviews. Neurology·Michael A Dimyan, Leonardo G Cohen
May 13, 2011·Neuropsychological Rehabilitation·Giovanni Berlucchi
May 28, 2011·Brain : a Journal of Neurology·Robert H AndresGary K Steinberg
Feb 19, 2013·Human Molecular Genetics·Robin LemmensVincent N Thijs
Oct 12, 2010·Stroke; a Journal of Cerebral Circulation·S Thomas Carmichael
Apr 27, 2012·Stroke; a Journal of Cerebral Circulation·Jullet HanMarion S Buckwalter
Apr 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laila ZaiLarry I Benowitz
Jan 29, 2011·Molecular Medicine·Na'ama A Shein, Esther Shohami
Feb 8, 2014·Brain Research·Shlomit DachirEsther Shohami
Jul 19, 2013·Neural Plasticity·Alessio FaralliDaniela Carulli
Dec 3, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Chayanin TangwiriyasakulMichel J A M van Putten
Feb 1, 2013·Stroke Research and Treatment·Jerzy Krupinski, Mark Slevin
Sep 28, 2012·Cellular and Molecular Life Sciences : CMLS·Xiaozhou HeYing Xia
Feb 14, 2016·Experimental Neurology·S Thomas CarmichaelEsther H Nie
May 31, 2011·Experimental Neurology·Masaki Ueno, Toshihide Yamashita
Apr 27, 2010·Current Opinion in Neurobiology·Fang Sun, Zhigang He
Oct 14, 2009·Neurobiology of Disease·Tonya M BlissGary K Steinberg
Sep 23, 2009·Neurobiology of Disease·George F Wittenberg
Jun 13, 2009·Neurobiology of Disease·Agnes Floel, Leonardo G Cohen
Jun 12, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Harriet E BarrattS Thomas Carmichael
Aug 27, 2015·Behavioural Brain Research·Lisa Y Y ZhouAndrew N Clarkson
Feb 18, 2012·Journal of Neurochemistry·Bettina ThauererGabriele Baier-Bitterlich
Jun 17, 2011·Developmental Psychobiology·Theresa A Jones, Stephanie C Jefferson
Jun 22, 2012·Annals of Neurology·Cindy T J van VelthovenCobi J Heijnen
Nov 26, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·S Thomas Carmichael
Nov 11, 2014·Annals of Neurology·Erin Burke QuinlanSteven C Cramer
Mar 27, 2012·Neuron·Jaimie D AdelsonRona G Giffard
Apr 23, 2016·Neurochemistry International·Haifa KassisZheng Gang Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Related Papers

Nature Reviews. Neuroscience
Timothy H Murphy, Dale Corbett
Proceedings of the National Academy of Sciences of the United States of America
Peng ChenLarry I Benowitz
© 2022 Meta ULC. All rights reserved