PMID: 6402515Jan 1, 1983Paper

Promoting effect of polychlorinated biphenyls on development of enzyme-altered islands in livers of weanling and adult rats

Journal of Cancer Research and Clinical Oncology
D Oesterle, E Deml

Abstract

The promoting activity of the commercial PCB mixture Clophen A 50 on preneoplastic, enzyme-altered islands in rat liver was investigated. Female Sprague-Dawley rats, 3 and 6 weeks old, were pretreated with nitrosamines for island initiation. Thereafter Clophen A 50 was administered repeatedly. Island development was examined between 2 and 12 weeks. Clophen A 50 by itself initiated few enzyme-altered islands, indicating a weak carcinogenicity. In Clophen A 50-treated adult rats, the majority of nitrosamine-initiated islands persisted. Without Clophen A 50 more than 80% of the islands disappeared between 6 and 12 weeks. Moreover, PCBs caused a striking increase in island number and total area during the last 2 weeks. In weanlings, islands persisted with or without the promoting stimulus. However, treatment with Clophen A 50 caused an earlier appearance and a higher number and total area of islands. The increase in the yield of DEN-initiated islands in both age groups is suggested to be due to the promotion of initiated but dormant cells. By pretreatment with N-NM instead of DEN, a shift to larger islands was observed additionally. The data indicate that weanlings are highly susceptible to initiation and promotion and may thus pro...Continue Reading

References

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Citations

Jan 1, 1988·Journal of Cancer Research and Clinical Oncology·B DenkH Greim
Jan 1, 1988·Journal of Cancer Research and Clinical Oncology·D Oesterle, E Deml
Feb 14, 2003·Toxicology and Applied Pharmacology·Parvaneh EspandiariLarry W Robertson
Jan 1, 1990·Experimental Pathology·D Oesterle, E Deml
May 1, 1985·Environmental Health Perspectives·S Sleight
Jan 1, 1990·Critical Reviews in Toxicology·E M SilberhornL W Robertson
Sep 15, 1984·Toxicology and Applied Pharmacology·E SchaefferW Goessner
Jul 15, 1986·International Journal of Cancer. Journal International Du Cancer·L M AndersonC W Riggs
Jun 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H S JenkeD Oesterle
Oct 20, 2006·Critical Reviews in Toxicology·Stefanie Knerr, Dieter Schrenk
Feb 25, 2003·Toxicologic Pathology·Carina IttrichAnnette Kopp-Schneider
Jan 1, 1988·American Journal of Industrial Medicine·E A EmmettA Alvares
Jul 1, 1989·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·L G LiD J Li
Jul 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H S JenkeJ Berndt
Jul 3, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Cecile MichelEric Boitier
Jul 16, 2002·Toxicology and Industrial Health·O M FaroonC De Rosa

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