Promoting effect of Roussin's red identified in pickled vegetables from Linxian China

Carcinogenesis
S J ChengI Chouroulinkov

Abstract

Roussin's red (dimethylthiotetranitrosodiiron) has been identified as a non-alkylating N-nitroso compound present in pickled vegetables from Linxian, a high risk area for oesophageal cancer in China. In vitro experiments showed that Roussin's red had no significant mutagenic and transforming activities at the doses used, but it did enhance transformation in C3H/10TI/2 cells initiated with 3-methylcholanthrene (0.1 microgram/mI) and it decreased the number of sebaceous glands and increased the epidermal thickness in short term skin tests. In this respect Roussin's red resembled 12-O-tetradecanoyl-phorbol-13-acetate and the results indicate that it may be a new naturally-occurring tumour promoter. The in vitro promoting effect of extracts of pickled vegetables that has been previously reported can be explained, at least in part, by the presence of Roussin's red. The possible role of Roussin's red in the aetiology of oesophageal cancer is discussed.

Citations

Sep 1, 1993·Mutation Research·J D TuckerA V Carrano
Sep 10, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ming-Hsun LinChau-Jong Wang
Sep 12, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C J WangW C Chang
Jan 1, 1986·Nutrition and Cancer·M H LiS J Cheng
Mar 31, 2009·Gastroenterology Clinics of North America·Farin KamangarSanford M Dawsey
Feb 15, 2015·Gastroenterology·Christian C AbnetFarin Kamangar
Dec 3, 1981·The New England Journal of Medicine·E Farber
Oct 29, 2009·British Journal of Cancer·F IslamiF Kamangar
Apr 14, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jian-Song RenFarhad Islami
Apr 11, 2002·Chemical Reviews·Anthony R Butler, Ian L Megson

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