Promoting effects of dimethylarsinic acid on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in rats

Carcinogenesis
H WanibuchiS Fukushima

Abstract

Arsenicals are epidemiologically significant chemicals in relation to induction of urinary bladder cancer in man. In the present study, we investigated the dose-dependent promotion potential of dimethylarsinic acid (DMA), a major metabolite of inorganic arsenicals in mammals, for rat urinary bladder carcinogenesis. In experiment 1, 6-week-old male F344 rats were treated with 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 4 weeks and then given one of several concentrations of DMA in their drinking water (groups 1-6: 0, 2, 10, 25, 50 and 100 p.p.m.) for 32 weeks. The development of preneoplastic lesions and tumors (papillomas and carcinomas) in the urinary bladder was enhanced by treatment with DMA in a dose-dependent manner. A significant increase in multiplicity of tumors (papillomas and carcinomas) was observed even at a low concentration of DMA (10 p.p.m.). On the other hand, no preneoplastic lesions and tumors were observed in the rats treated with DMA alone. In experiment 2, different concentrations of DMA (groups 1-4: 0, 10, 25 and 100 p.p.m.) in drinking water were administered to the rats for 8 weeks without prior initiation by BBN. A significant increase in the 5-bromo-2'-deoxyuridine labeling index and alterati...Continue Reading

Citations

Jun 15, 2001·Teratogenesis, Carcinogenesis, and Mutagenesis·M SordoE Rojas
Dec 4, 2003·Mutation Research·Toby G Rossman
Jul 28, 2004·Toxicology and Applied Pharmacology·Koichi KurodaGinji Endo
Sep 19, 2003·Toxicology and Applied Pharmacology·Michael F HughesDavid J Thomas
Oct 16, 1999·Toxicology·M F HughesD J Thomas
Jun 22, 2002·Toxicology Letters·Michael F Hughes
Jun 22, 2002·Toxicology Letters·Jian Ping WangJack C Ng
May 29, 1998·Mutation Research·E KashiwadaG Endo
Aug 30, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shugo SuzukiSamuel M Cohen
Jul 14, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael F HughesDavid J Thomas
May 3, 2001·Environmental Health Perspectives·J Huff
Jul 11, 2013·Journal of Exposure Science & Environmental Epidemiology·Jefferey L BurgessR Clark Lantz
Nov 9, 2000·Archives of Biochemistry and Biophysics·S AhmadW R Cullen
Jul 7, 2009·Ecotoxicology and Environmental Safety·Maciej StepnikKonrad Rydzyński
Mar 6, 2007·Toxicology and Applied Pharmacology·Reeder SamsAnna Lowit
Nov 4, 2006·The Science of the Total Environment·Manonmanii KrishnamohanJack C Ng
Jun 2, 2005·International Journal of Cancer. Journal International Du Cancer·Shigeyuki SugieHideki Mori
Apr 20, 2007·Cancer Science·Anna KinoshitaShoji Fukushima
Nov 18, 2006·Toxicology and Applied Pharmacology·Samuel M CohenX Chris Le
Apr 1, 2006·Mutation Research·Soile Tapio, Bernd Grosche
Aug 5, 2015·Regulatory Toxicology and Pharmacology : RTP·Michael R GarryJohn M DeSesso
Feb 21, 2006·Environmental Research·Arun B JosyulaJefferey L Burgess

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