Promoting growth in chronic inflammatory disease: lessons from studies of the growth plate

Hormone Research
S F Ahmed, L Sävendahl

Abstract

Growth disorders are commonly observed in children with chronic inflammatory disease. It is likely that these disorders are mediated by a combination of factors, including the disease process and its treatment (with drugs such as glucocorticoids [GCs]). These factors affect the growth hormone-insulin-like growth factor I (IGF-I) axis, which is crucial for promoting linear growth at the level of the growth plate. Recent advances in our knowledge of the effects of GCs and proinflammatory cytokines on the growth plate have led to an improved understanding of the biological rationale for the use of growth-promoting therapy in children with chronic inflammatory disease and concurrent growth retardation. Both GCs and proinflammatory cytokines can adversely affect a number of components of growth plate chondrogenesis, and these effects can be ameliorated by raising local IGF-I exposure. However, this intervention does not lead to complete normalization of the growth plate. In children with chronic inflammation, the cornerstone of improving growth remains the judicious use of GCs while ensuring effective control of the disease process.

Citations

Sep 17, 2013·Paediatric Drugs·Mabrouka A AltowatiS Faisal Ahmed
Apr 16, 2013·American Journal of Epidemiology·Amie E HwangWendy Cozen
Oct 25, 2012·Science Signaling·Lars Sävendahl
Nov 1, 2012·Science Signaling·Evangelia CharmandariGeorge P Chrousos
Apr 1, 2018·Clinical and Translational Science·Shlomit Radom-AizikGregory R Adams
Nov 10, 2018·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·R MeyerC Venter
Mar 23, 2012·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Rosan MeyerNeil Shah
Apr 9, 2014·Journal of Molecular Endocrinology·Bettina SederquistLars Sävendahl
Aug 16, 2019·Tissue Engineering and Regenerative Medicine·Peter M van der Kraan
Sep 5, 2012·Experimental Biology and Medicine·Carol A EversonJeffrey M Toth
Apr 25, 2020·Journal of Clinical Medicine·María Guillán-FrescoRodolfo Gómez

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