Promoting inertial cavitation by nonlinear frequency mixing in a bifrequency focused ultrasound beam

Ultrasonics
Izella SaletesJean-Christophe Bera

Abstract

Enhancing cavitation activity with minimal acoustic intensities could be interesting in a variety of therapeutic applications where mechanical effects of cavitation are needed with minimal heating of surrounding tissues. The present work focuses on the relative efficiency of a signal combining two neighbouring frequencies and a one-frequency signal for initiating ultrasound inertial cavitation. Experiments were carried out in a water tank, using a 550kHz piezoelectric composite spherical transducer focused on targets with 46μm roughness. The acoustic signal scattered, either by the target or by the cavitation bubbles, is filtered using a spectral and cepstral-like method to obtain an inertial cavitation activity measurement. The ultrasound excitations consist of 1.8ms single bursts of single frequency f(0)=550kHz excitation, in the monofrequency case, and of dual frequency f(1)=535kHz and f(2)=565kHz excitation, in the bifrequency case. It is shown that depending on the value of the monofrequency cavitation threshold intensity the bifrequency excitation can increase or reduce the cavitation threshold. The analysis of the thresholds indicates that the mechanisms involved are nonlinear. The progress of the cavitation activity bey...Continue Reading

References

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Citations

Jul 9, 2014·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control· Sijia Guo Xiaoning Jiang
Jan 25, 2011·IEEE Transactions on Bio-medical Engineering·Ali KoşarDevrim Gozuacik
Sep 23, 2014·BioMed Research International·Izella SaletesJean-Christophe Béra
Jan 13, 2012·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·William Apoutou N'djinRajiv Chopra
May 25, 2011·Physics in Medicine and Biology·Vincent AuboirouxRares Salomir
Oct 17, 2019·Australasian Physical & Engineering Sciences in Medicine·Zahra Sadat TabatabaeiAmeneh Sazgarnia

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