PMID: 15335001Sep 1, 2004Paper

Promoting the cytocompatibility of polyurethane scaffolds via surface photo-grafting polymerization of acrylamide

Journal of Materials Science. Materials in Medicine
Yabin ZhuJiacong Shen

Abstract

Polyurethane (PU) porous scaffolds were modified by grafting polymerization of acrylamide (AAm) initiated under UV light. A pre-adsorbing-monomer method was used beforehand. FTIR-ATR spectroscopy and X-ray photoelectron spectroscopy (XPS) measurements confirmed the presence of grafted PAAm on PU scaffolds. The measurement of water adsorption demonstrated the improvement of hydrophilicity after PU scaffolds were grafted with polyacrylamide (PAAm). The PAAm grafting degree related to the amount of AAm adsorbed, average pore diameter, and the degree of porosity. This study shows that higher degree of porosity and bigger porous areas yielded larger amounts of absorbed AAm and higher grafting degrees. In vitro human endothelial cell cultures of PU scaffolds modified with hydrophilic PAAm showed better cytocompatibility than the control matrix.

Citations

Nov 7, 2008·Journal of Materials Science. Materials in Medicine·J M Silva MarquesM H Fernandes
Aug 9, 2007·Colloids and Surfaces. B, Biointerfaces·Zuwei MaChangyou Gao
Jun 15, 2013·Journal of Biomedical Materials Research. Part a·Venkata P MantripragadaAmbalangodage C Jayasuriya
Jun 27, 2009·Journal of Biomedical Materials Research. Part a·Nurdan OzkucurT K Monsees
Sep 19, 2006·Biomaterials·Ian C BonzaniMolly M Stevens
Mar 28, 2009·Journal of Biomaterials Science. Polymer Edition·Yingjun WangQichun Zhao

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