Promoting Vasa Vasorum Neovascularization of Vein Grafts Extenuates Hypoxia of the Wall and Its Subsequent Influence on Intimal Hyperplasia

Chinese Medical Journal
Rongjiang ZouSong Xue

Abstract

The autologous saphenous vein is the most common conduit for coronary artery bypass grafting, but the vein graft disease will occur. This study used Matrigel basement membrane matrix with many different growth factors to promote vasa vasorum neovascularization and extenuate the hypoxia to improve remodeling. This study observed the hypoxia and thickness of the vein grafts at different times. Normal veins and vein grafts with 15 min of ischemia one day postoperatively were harvested in the neck of rabbits. Paired vein grafts with 15 min ischemia bilaterally (control vs. Matrigel basement membrane matrix) were performed and harvested at 2, 6, and 12 weeks postoperatively. The rabbits were randomly divided into four postoperative groups (six rabbits in each group): Group 1, one day postoperatively; Group 2, 2 weeks postoperatively; Group 3, 6 weeks postoperatively; and Group 4, 12 weeks postoperatively. The dimensions of vessel wall were captured, and the mean thicknesses of intima, media, and adventitia were measured. The hypoxia-inducible factor (HIF)-1α and HIF-2α labeling indices of intima, media, and adventitia were also measured. In Group 1, the labeling index of HIF-1α was high in the normal vein and decreased significantly...Continue Reading

References

Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Oct 31, 1998·Current Opinion in Genetics & Development·G L Semenza
Feb 13, 2001·Cardiovascular Research·E M ConwayP Carmeliet
Jan 28, 2003·Journal of Cardiac Surgery·Jamie Y JeremyGianni D Angelini
Aug 24, 2004·Current Vascular Pharmacology·Jamie Y JeremyGianni D Angelini
Oct 23, 2010·Molecular Cell·Amar J MajmundarM Celeste Simon
May 21, 2013·The Annals of Thoracic Surgery·Mats DreifaldtDomingos Souza

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

SPSS
YRMV

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