Promotion by dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice

Cancer Letters
M A Pereira, J B Phelps

Abstract

Hepatic tumor promoting activity was determined for dichloroacetic acid (DCA) and trichloroacetic acid (TCA) in female B6C3F1 mice initiated on day 15 of age with 25m/kg N-methyl-N-nitrosourea (MNU). The mice were administered the chloroacetic acids in drinking water starting at 7 weeks of age and continuing until sacrificed 31 or 52 weeks later. Both chloroacetic acids promoted MNU-initiated foci and tumors, however their concentration-response relationships differed being exponential and linear for DCA or TCA, respectively. Lesions promoted by DCA but not by TCA, regressed upon termination of exposure at 31 weeks. Foci and tumors promoted by DCA were eosinophilic and contained glutathione S-transferase-pi(GST-pi), while TCA promoted basophilic tumors lacking GST-pi. Hence, tumor promotion by DCA and TCA appeared to differ both with respect to their concentration-response relationships and to the characteristics of precancerous lesions and tumors.

Associated Clinical Trials

References

Feb 1, 1991·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·A B DeAngeloG R Olson
Apr 1, 1987·Toxicology and Applied Pharmacology·T L Goldsworthy, J A Popp
Jan 1, 1987·Toxicologic Pathology·S D Vesselinovitch
Apr 1, 1980·Bulletin of Environmental Contamination and Toxicology·W H RapsonV V Butsky

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Citations

Apr 5, 2001·Journal of Applied Toxicology : JAT·J Kato-WeinsteinR J Bull
Apr 3, 2001·Journal of Biochemical and Molecular Toxicology·R GeM A Pereira
Oct 27, 2009·Critical Reviews in Toxicology·David J JollowLawrence C Mohr
Sep 21, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ana I Faustino-RochaMário Ginja
Apr 10, 2012·Mutation Research·Jane C Caldwell
Feb 1, 1997·Regulatory Toxicology and Pharmacology : RTP·K T Bogen, L S Gold

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