PMID: 9437805Jan 23, 1998Paper

Promotion by Helicobacter hepaticus-induced hepatitis of hepatic tumors initiated by N-nitrosodimethylamine in male A/JCr mice

Toxicologic Pathology
B A DiwanL M Anderson

Abstract

A new murine Helicobacter species, Helicobacter hepaticus, infects the livers of mice, causing a progressive chronic active hepatitis culminating in hepatocellular tumors. To examine the role of chronic H. hepaticus infection in carcinogenesis, H. hepaticus-infected male infant mice of A/JCr strain were given a single i.p. dose of N-nitrosodimethylamine (NDMA). Noninfected A/J mice similarly treated with NDMA served as controls. The effect of hepatitis induced by H. hepaticus was studied for 64 wk. At 31-36 wk, the incidence of hepatocellular adenomas in infected mice was significantly higher than in noninfected mice (82 vs 52%; p = 0.05). The multiplicity of hepatocellular tumors was also significantly higher in infected mice compared to noninfected mice (3.2 +/- 0.09 vs 0.09 +/- 0.2; p = 0.03). At 51-64 wk, many (10/18) infected mice developed hepatocellular carcinomas while only 2 of 19 control mice developed such tumors (p = 0.005). Overexpression of cyclin D was observed in hepatocytes as well as adenomas induced by NDMA in H. hepaticus-infected mice, suggesting its role in inflammation, abnormal cell growth, and early neoplasia. High molecular weight keratins were highly expressed in hyperplastic oval cells in hepatitis a...Continue Reading

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Citations

Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T SakamotoA J Demetris
Jan 9, 2001·Clinical Microbiology Reviews·J V Solnick, D B Schauer
Jun 29, 2002·Journal of Clinical Microbiology·James G FoxJohn M Cullen
Apr 27, 2012·Proteome Science·Arinze S OkoliGeorge L Mendz
Oct 23, 2008·Environmental Health Perspectives·Bhalchandra A DiwanLucy M Anderson
Dec 10, 2009·Future Microbiology·Quoc V TuGeorge L Mendz
Sep 27, 2014·International Journal of Environmental Research and Public Health·Mitsuko L Yamamoto, Robert H Schiestl
Oct 30, 2004·Toxicologic Pathology·Samuel R BoutinJames G Fox
Feb 24, 2001·Veterinary Pathology·C BraytonC A Montgomery
Oct 10, 2002·Toxicologic Pathology·Vladimir S TurusovGary A Boorman
Jan 14, 2011·Toxicologic Pathology·Bob ThoolenJerrold M Ward
Dec 18, 2002·Helicobacter·Ulrich R M BohrPeter Malfertheiner

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