Promotion Effects of Ultra-High Molecular Weight Poly-γ-Glutamic Acid on Wound Healing

Journal of Microbiology and Biotechnology
Jae-Chul ChoiMoon-Hee Sung

Abstract

We examined the in vivo efficacy of ultra-high molecular weight poly-γ-glutamic acid (UHMW γ-PGA) for wound healing. The wound area was measured by a ruler and documented by digital photography before the animals were sacrificed at days 8 and 16 post wounding. The areas of wounds treated with UHMW γ-PGA were significantly decreased on days 8 and 16, as compared with those receiving a control treatment, and more than 70% of the UHMW γ-PGAtreated area was repaired by day 8. Hematoxylin and eosin staining confirmed that the epidermis had regenerated in the UHMW γ-PGA-treated wounds. At 16 days post wounding, collagen pigmentation and cross-linking were increased as compared with the control groups, and greater regeneration of blood vessels had occurred in UHMW γ-PGA-treated groups. Increased levels of transforming growth factor-beta and β-catenin were also observed in skin samples collected from UHMW γ-PGA-treated animals on days 8 and 16 post incision. Taken together, these findings suggest that UHMW γ-PGA promotes wound healing in vivo.

Citations

Aug 20, 2016·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Kars P ValkeringPaul W Ackermann
Jul 25, 2015·Phytotherapy Research : PTR·Walter ChingwaruJose Jackson
Nov 20, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jirapak RuttanapattanakulWutigri Nimlamool
Apr 4, 2021·Polymers·Jonathan David HinchliffeIpsita Roy

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