PMID: 2116170Jul 24, 1990Paper

Promotion of acid-induced membrane fusion by basic peptides. Amino acid and phospholipid specificities

Biochimica Et Biophysica Acta
J Bondeson, R Sundler

Abstract

The ability of oligo- and polymers of the basic amino acids L-lysine, L-arginine, L-histidine and L-ornithine to induce lipid intermixing and membrane fusion among vesicles containing various anionic phospholipids has been investigated. Among vesicle consisting of either phosphatidylinositol or mixtures of phosphatidic acid and phosphatidylethanolamine rapid and extensive lipid intermixing, but not complete fusion, was induced at neutral pH by poly-L-ornithine or L-lysine peptides of five or more residues. When phosphatidylcholine was included in the vesicles, the lipid intermixing was severely inhibited. Such lipid intermixing was also much less pronounced among phosphatidylserine vesicles. Poly-L-arginine provoked considerable leakage from the various anionic vesicles and caused significantly less lipid intermixing than L-lysine peptides at neutral pH. When the addition of basic amino acid polymer was followed by acidification to pH 5-6, vesicle fusion was induced. Fusion was more pronounced among vesicles containing phosphatidylserine or phosphatidic acid than among those containing phosphatidylinositol, and occurred also with vesicles whose composition resembles that of cellular membranes (i.e., phosphatidylcholine/phosphat...Continue Reading

References

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R SundlerP R Vagelos
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·F Szoka, D Papahadjopoulos
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Jul 7, 1981·Biochemistry·D K StruckR E Pagano

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Citations

Apr 1, 1992·The International Journal of Biochemistry·T Cserháti, M Szögyi
Jun 1, 1991·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R H Goodwin
Jun 10, 2009·Biochimica Et Biophysica Acta·Adam A StrömstedtMartin Malmsten
Mar 17, 1999·Biochimica Et Biophysica Acta·F E GarrettR A Koch
Jan 3, 2006·Colloids and Surfaces. B, Biointerfaces·Aiping ZhuFeng Zhao
May 16, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Cuicui SuDehai Liang
Jun 1, 1995·Bioscience Reports·R M Epand, W Lim
May 29, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·J L Thomas, D A Tirrell1

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