Promotion of angiogenesis by human endometrial lymphocytes

Immunological Investigations
Caroline DunkRebecca L Jones

Abstract

The human endometrium is a unique tissue that undergoes dramatic monthly remodeling during the menstrual cycle in preparation for an implanting conceptus. This remodeling involves sequential proliferation and differentiation of endometrial stromal and epithelial cells, coupled with extensive angiogenesis and infiltration of a specific specialized immune cell subset. Increasing evidence points to an essential role for these maternal leukocytes in stimulating the endometrial angiogenesis, and we propose that they also play a key role in the decidual vascular transformation. Aberrant endometrial angiogenesis, decidualisation and vascular transformation is thought to underlie many pathologies of pregnancy, from infertility to the development of preeclampsia and Intra Uterine Growth Restriction. In this chapter we review the cellular processes associated with each stage of endometrial and decidual transformation, detailing the role of the immune cell populations and the angiogenic and chemotactic factors secreted by them.

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Citations

Sep 17, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Jane E Girling, Peter A W Rogers
Oct 11, 2011·Journal of Thrombosis and Haemostasis : JTH·S DrewloJ C P Kingdom
Feb 6, 2013·Journal of Cellular and Molecular Medicine·Oksana ShynlovaStephen J Lye
Mar 19, 2011·Journal of Reproductive Immunology·J L V ShawA W Horne
Dec 15, 2010·Best Practice & Research. Clinical Obstetrics & Gynaecology·Margreet Plaisier
May 23, 2012·Reproductive Sciences·Oksana ShynlovaStephen J Lye
May 25, 2011·Obstetrics and Gynecology·Mara L SobelSascha Drewlo
Mar 18, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hui ZhaoDavid K Stevenson
Aug 20, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hagai AmsalemCaroline E Dunk

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