Promotion of graft survival by photothrombotic occlusion of corneal neovascularization.

Archives of Ophthalmology
G CorrentB D Watson

Abstract

Corneal neovascularization may reduce the success of penetrating keratoplasty. Photothrombosis using intravenous rose bengal and argon laser irradiation has shown promise for occluding corneal vessels. It is therefore conceivable that photothrombosis can improve the graft survival in vascularized corneas. Using intracorneal 7-0 silk sutures as the stimuli, corneal neovascularization was induced in 1 eye each of 19 New Zealand white rabbits. Eleven eyes received photothrombosis. Successful occlusion with subsequent regression was verified by corneal fluorescein angiography. Three were assigned for observation. Six of 8 eyes receiving grafts from an outbred rabbit donor after photothrombosis remained clear during 6.5 to 18.5 weeks of follow-up, while vascularization and opacity occurred in 7 of 8 control eyes without photothrombosis. These results indicate that prior photothrombotic occlusion of corneal vessels can significantly improve graft survival in this experimental model and may have clinical applications.

Citations

Jan 28, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C FrammeR Birngruber
Apr 18, 2009·Seminars in Ophthalmology·Sandra R MontezumaJoan W Miller
Sep 4, 2012·Trends in Cardiovascular Medicine·Hyun-Young Koo, Tsutomu Kume
Nov 3, 2015·Journal français d'ophtalmologie·Y BenayounJ-L Salomon
Jul 17, 2007·American Journal of Ophthalmology·Kyung-Chul YoonKyu Youn Ahn
Jan 1, 1993·Lasers in Surgery and Medicine·I G PallikarisI A Panagopoulos
Jun 27, 2003·Cornea·Maurizio FossarelloAntonina Serra
Mar 11, 2011·Cornea·Deepak Gupta, Chris Illingworth
Jun 7, 2012·Cornea·Miltiadis PapathanassiouPanagiotis G Theodossiadis
Aug 14, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Masashi MuramatsuTakashi Minami
Oct 1, 1990·Journal of Clinical Laser Medicine & Surgery·F FrankF Wondrazek
Apr 21, 2004·Cornea·Maurizio FossarelloAntonina Serra
Mar 20, 2020·Current Drug Targets·Giuseppe GiannaccareMassimo Busin

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