Promotion of PDT efficacy by a Bcl-2 antagonist

Photochemistry and Photobiology
David Kessel

Abstract

Photodynamic therapy (PDT) directed against the endoplasmic reticulum (ER) is also known to target antiapoptotic Bcl-2 family proteins. This effect is associated with the initiation of both apoptosis, a cell death pathway, and autophagy, an organelle recycling system that can lead to survival or cell death. In this study, we examined the ability of the Bcl-2 antagonist HA14-1 to promote the photodynamic efficacy of PDT directed at the ER. At concentrations that independently caused only a small loss of viability, HA14-1 markedly enhanced the proapoptotic and phototoxic effects of ER photodamage. These results provide additional evidence that the antiapoptotic properties of Bcl-2 constitute an important determinant of photokilling, and demonstrate that synergistic effects can result when PDT is coupled with pharmacologic suppression of Bcl-2 function.

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Citations

Aug 8, 2009·Photochemistry and Photobiology·Michael PriceDavid Kessel
Nov 8, 2014·International Journal of Molecular Sciences·Andrej WagnerTobias Kiesslich
Feb 13, 2016·Photodiagnosis and Photodynamic Therapy·Malgorzata WachowskaJakub Golab
Nov 26, 2009·Journal of Photochemistry and Photobiology. B, Biology·Peter FerencPeter Fedorocko
Nov 14, 2012·The Journal of Pharmacy and Pharmacology·Mary TomekCrispin R Dass
May 28, 2011·CA: a Cancer Journal for Clinicians·Patrizia AgostinisJakub Golab
Jul 24, 2008·Journal of Porphyrins and Phthalocyanines·David Kessel
Nov 22, 2019·Journal of Lasers in Medical Sciences·Shima AfrasiabiAbbas Bahador

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Related Concepts

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BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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