Promotion of prostatic metastatic migration towards human bone marrow stoma by Omega 6 and its inhibition by Omega 3 PUFAs

British Journal of Cancer
M D BrownN W Clarke

Abstract

Epidemiological studies have shown not only a relationship between the intake of dietary lipids and an increased risk of developing metastatic prostate cancer, but also the type of lipid intake that influences the risk of metastatic prostate cancer. The Omega-6 poly-unsaturated fatty acid, Arachidonic acid, has been shown to enhance the proliferation of malignant prostate epithelial cells and increase the risk of advanced prostate cancer. However, its role in potentiating the migration of cancer cells is unknown. Here we show that arachidonic acid at concentrations <or=5 microM is a potent stimulator of malignant epithelial cellular invasion, which is able to restore invasion toward hydrocortisone-deprived adipocyte-free human bone marrow stroma completely. This observed invasion is mediated by the arachidonic acid metabolite prostaglandin E2 and is inhibited by the Omega-3 poly-unsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid at a ratio of 1 : 2 Omega-3 : Omega-6, and by the COX-2 inhibitor NS-398. These results identify a mechanism by which arachidonic acid may potentiate the risk of metastatic migration and secondary implantation in vivo, a risk which can be reduced with the uptake of Omega-3 poly-unsat...Continue Reading

References

Jun 1, 1977·Journal of Cellular Physiology·T M DexterL G Lajtha
Oct 15, 1976·International Journal of Cancer. Journal International Du Cancer·A P LanierW B Hurlburt
Aug 1, 1984·American Journal of Epidemiology·D A SnowdonW Choi
Jan 1, 1980·Leukemia Research·I R ToogoodL G Lajtha
Dec 1, 1994·Cancer Metastasis Reviews·K V HonnW Hagmann
Oct 6, 1993·Journal of the National Cancer Institute·E GiovannucciW C Willett
Apr 30, 1998·Biochimica Et Biophysica Acta·Y DenizotV Praloran
Jul 14, 1998·Molecular Cell·E MuellerB M Spiegelman
Nov 27, 1999·Pharmacology & Therapeutics·D P Rose, J M Connolly
Mar 7, 2000·Mediators of Inflammation·Y DenizotV Praloran
Jun 14, 2001·Lancet·P TerryA Wolk
Jun 18, 2002·The Journal of Endocrinology·J E Compston
Jul 30, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·G MamalakisA Kranidis
Dec 24, 2002·Prostate Cancer and Prostatic Diseases·L J ScottS H Lang
May 23, 2003·Journal of Cellular Biochemistry·Yan-Xi SunRussell S Taichman
Sep 27, 2003·BJU International·F H FaasD E Johnson
Feb 21, 2004·Biochemical and Biophysical Research Communications·Jagadananda Ghosh
Aug 12, 2004·International Journal of Cancer. Journal International Du Cancer·Roberta M MorettiPatrizia Limonta
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Devendra S Dandekar, Bal L Lokeshwar
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Manish I PatelAndrew J Dannenberg
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Apr 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Scott William Roy, Walter Gilbert
May 11, 2005·Current Medical Research and Opinion·Nigel Harrison, Brihad Abhyankar
Jun 25, 2005·Journal of Vascular Research·Florian KrotzHae-Young Sohn
Jul 26, 2005·Acta Pharmacologica Sinica·Cheng LuoLars Bohlin
Aug 1, 2004·Molecular and Cellular Biochemistry·Darren J Holub, Bruce J Holub

❮ Previous
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Citations

Jun 28, 2014·BioMed Research International·Nadia Rucci, Adriano Angelucci
Dec 4, 2008·Asian Journal of Andrology·Noel W ClarkeMick D Brown
May 27, 2009·Indian Journal of Urology : IJU : Journal of the Urological Society of India·H Krishna Moorthy, P Venugopal
Nov 6, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Helena GleissmanPer Kogner
Mar 4, 2011·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Pawni PrabhatK Singh
Mar 15, 2013·Nature Reviews. Cancer·S Patricia Becerra, Vicente Notario
Sep 6, 2011·Critical Reviews in Food Science and Nutrition·Aleix Sala-Vila, Philip C Calder
Jun 14, 2013·BioMed Research International·Zhennan GuYong Q Chen
Aug 25, 2015·BioMed Research International·Karsten H WeylandtGabriella Calviello
Jul 28, 2016·Frontiers in Endocrinology·Mackenzie Katheryn HerroonIzabela Podgorski
Oct 16, 2007·Nutrition·Akifumi HagiKazumi Yagasaki
Dec 30, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·J P NobesR W Laing
Jan 1, 2012·Cancers·Christina Hägglöf, Anders Bergh
Jun 21, 2008·International Journal of Cancer. Journal International Du Cancer·Michael P EndsleyKasem Nithipatikom
Feb 7, 2018·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Kathleen M McClainAndrew F Olshan
Sep 13, 2007·Cancer Metastasis Reviews·Yong Q ChenIsabelle M Berquin
Oct 26, 2007·Nutrition Reviews·Susan E BerkowTrulie Ankerberg-Nobis
Jul 16, 2010·The Prostate·Eugene V VykhovanetsSanjay Gupta
Apr 26, 2012·British Journal of Cancer·M BrownN Clarke
Mar 25, 2015·Clinical & Experimental Metastasis·Aimalie L HardawayIzabela Podgorski
Sep 17, 2010·The American Journal of Clinical Nutrition·Konrad M SzymanskiLorelei A Mucci
Jul 25, 2019·Adipocyte·Yoon Jin Cha, Ja Seung Koo
Jan 9, 2014·Cancer Metastasis Reviews·Aimalie L HardawayIzabela Podgorski
Jul 29, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Andreia MatosRicardo Ribeiro
Mar 18, 2015·Hormone Molecular Biology and Clinical Investigation·Jonathan DiedrichIzabela Podgorski
May 22, 2007·The Journal of Nutrition·Neil E HubbardKent L Erickson
Nov 29, 2017·Molecular and Clinical Oncology·Thierry RoumeguèreFouad Aoun
Apr 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nga-Tsing TangJoanna L Denbigh
Jul 20, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·H Chkourko GuskyI Podgorski

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Methods Mentioned

BETA
FCS
infrared microscopy
flow cytometry
FACS
confocal microscopy

Software Mentioned

Spotlight
Imaris
ImageJ Image Analysis

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