PMID: 4727914Sep 1, 1973Paper

Promotion of replication in lymphoid cells by specific thiols and disulfides in vitro. Effects on mouse lymphoma cells in comparison with splenic lymphocytes

The Journal of Experimental Medicine
J D Broome, M W Jeng

Abstract

Numerous lines of mouse lymphoid tumors (13 of 22 tested) showed, with increased sensitivity, a property of normal mouse splenic lymphocytes, the potential for growth promotion in vitro by specific thiols added to standard culture media. For lymphoma L1210 (V), structure activity relationships were examined; 9 of 30 thiols promoted growth; the most active was alpha-thioglycerol, effective at 0.2 microM. Thiols became oxidized under conditions of tissue culture and had half-lives of less than 8 h. Disulfides of active thiols promoted growth of lymphoma cells. The mitogenic response of splenic lymphocytes to lectins was increased by thiols-disulfides which promoted the growth of lymphoma cells, but the response varied with the mitogen preparation used and under some conditions thiols-disulfides were inhibitory.

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Citations

Jan 1, 1994·Journal of Cancer Research and Clinical Oncology·M InomataS Tokura
Dec 15, 1977·Experientia·K BobrzeckaJ Rybarska
Oct 1, 1987·Agents and Actions·P C ChenJ D Broome
Mar 1, 1986·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·I HishinumaS Bannai
Jun 17, 2009·Archives of Microbiology·Miriam Daniel-HoffmannYeshayahu Nitzan
Nov 28, 1985·Journal of Immunological Methods·E Sjögren-Jansson, S Jeansson
Jan 1, 1984·Developmental and Comparative Immunology·P A Middleton, W W Bullock
Nov 1, 1988·Immunopharmacology·J A Oben, J C Foreman
Dec 1, 1985·Veterinary Immunology and Immunopathology·C HammerbergE V Debuysscher
Nov 1, 1990·Veterinary Immunology and Immunopathology·M A QureshiM D Ficken
Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J I Toohey
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·N RosenbergC D Scher
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P TanapatJ D Broome
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P J BirckbichlerH A Carter
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·W N ValentineR A Brockway
Apr 1, 1974·The Journal of Experimental Medicine·M J BevanM Cohn
Aug 1, 1974·The Journal of Experimental Medicine·G J GleichK G Mann
Aug 1, 1975·The Journal of Experimental Medicine·R K Zwerner, R T Acton
Oct 1, 1975·The Journal of Experimental Medicine·C F Nathan, W D Terry
Dec 1, 1975·The Journal of Experimental Medicine·D MetcalfG A Gutman
Apr 1, 1977·The Journal of Experimental Medicine·H G OpitzH D Flad

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