PMID: 4727914Sep 1, 1973Paper

Promotion of replication in lymphoid cells by specific thiols and disulfides in vitro. Effects on mouse lymphoma cells in comparison with splenic lymphocytes

The Journal of Experimental Medicine
J D Broome, M W Jeng


Numerous lines of mouse lymphoid tumors (13 of 22 tested) showed, with increased sensitivity, a property of normal mouse splenic lymphocytes, the potential for growth promotion in vitro by specific thiols added to standard culture media. For lymphoma L1210 (V), structure activity relationships were examined; 9 of 30 thiols promoted growth; the most active was alpha-thioglycerol, effective at 0.2 microM. Thiols became oxidized under conditions of tissue culture and had half-lives of less than 8 h. Disulfides of active thiols promoted growth of lymphoma cells. The mitogenic response of splenic lymphocytes to lectins was increased by thiols-disulfides which promoted the growth of lymphoma cells, but the response varied with the mitogen preparation used and under some conditions thiols-disulfides were inhibitory.


Aug 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·D B Fisher, G C Mueller
Feb 1, 1972·Cellular Immunology·R E ClickB J Alter
Oct 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·A K FowlerA C Quatrale
Aug 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·S D Balk
Oct 1, 1968·Analytical Chemistry·T J Bydalek, J E Poldoski
Jun 28, 1969·Nature·R HirschhornG Weissmann
Apr 1, 1966·Experimental Cell Research·D J HutchisonM R Bjerregaard
Dec 5, 1958·Annals of the New York Academy of Sciences·G A FISCHER
Jul 1, 1959·Virology·R DULBECCO, G FREEMAN
Apr 1, 1964·Biochemistry·W W CLELAND

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