PMID: 8968023Dec 1, 1996Paper

Promotion of the osteogenetic activity of recombinant human bone morphogenetic protein by prostaglandin E1

Bone
I OnoY Kuboki

Abstract

We investigated the promotive effect of prostaglandin (PG) E1 on the osteogenetic activity of bone morphogenetic protein (BMP) using porous chemically synthesized hydroxyapatite ceramic (HAP) pellets as the carrier. After treating the pellets with recombinant human (rh) BMP-2 with or without PGE1, both of which were used at two different concentrations, they were inserted beneath the cranial periosteum of a rabbit. The degree of osteogenesis and osteoconductivity was then examined histopathologically as well as by means of an image-analyzing procedure. Results showed that there was extensive bone formation around the pellets as early as 3 weeks after insertion in the group, which received pellets treated with a relatively large amount of rhBMP alone as well as in the group receiving pellets treated with a small amount of rhBMP combined with PGE1. In the later group, the extent of bone formation was dose-dependent. Subsequent osteogenesis within the pores of the pellets in these groups slowly progressed over time, and by 9 weeks after the insertion, most of the pellet pores had filled with newly generated bone. In addition, the groups which received pellets treated with PGE1 alone also showed osteogenesis as demonstrated by oste...Continue Reading

References

Oct 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·M R Urist, A J Mikulski
Nov 1, 1992·Plastic and Reconstructive Surgery·I OnoY Kuboki
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E A WangP LaPan
Aug 1, 1989·Plastic and Reconstructive Surgery·T E GrengaT W Bauer
Aug 1, 1989·Plastic and Reconstructive Surgery·K E Salyer, C D Hall
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E A WangJ M Wozney
Nov 12, 1965·Science·M R Urist
Jun 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·M R UristR J DeLange
Aug 1, 1980·Journal of Maxillofacial Surgery·R A FinnJ A Brammer
Nov 1, 1980·The Journal of Pediatrics·K SoneT Kuroume
Feb 1, 1995·The Journal of Clinical Investigation·M W LongK G Mann
Jul 1, 1993·The Journal of Craniofacial Surgery·J Hollinger
Jan 1, 1993·Plastic and Reconstructive Surgery·H S ByrdK Shewmake
Feb 1, 1996·Plastic and Reconstructive Surgery·G H Rudkin, T A Miller
Aug 1, 1996·Burns : Journal of the International Society for Burn Injuries·H GunjiF Kaneko

❮ Previous
Next ❯

Citations

Jun 18, 2009·International Orthopaedics·Feng-chao ZhaoZhao-hui Liu
Sep 1, 2000·Advanced Drug Delivery Reviews·C A Kirker-Head
Nov 25, 2000·Journal of Pharmacological and Toxicological Methods·A S DumontR J Hurlbert
Nov 6, 2002·Journal of Periodontology·Michael R ThylinRichard A Reinhardt
Sep 25, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Renwen ZhangMonica V Hawkins
Dec 14, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·J A JansenA G Mikos
Aug 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S A ClarkeN Rushton
Mar 15, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xinhua LinLouis A Peña
Apr 4, 2002·Acta Orthopaedica Scandinavica·Thomas B JensenKjeld Søballe
Dec 12, 2007·The Journal of Hand Surgery·Anneluuk L C Lindenhovius, Jesse B Jupiter
Apr 20, 2004·The Journal of the American Academy of Orthopaedic Surgeons·Frederick S KaplanEileen M Shore
Dec 18, 2001·Nutrition·U N Das
Sep 6, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·U N Das

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.