Promotive effect of the platinum moiety on the DNA cleavage activity of copper-based artificial nucleases

Inorganic Chemistry
Xindian DongZijian Guo

Abstract

Copper-based artificial metallonucleases are likely to satisfy more biomedical requirements if their DNA cleavage efficiency and selectivity could be further improved. In this study, two copper(II) complexes, [CuL(1)Cl(2)] (1) and [CuL(2)Cl(2)] (2), and two copper(II)-platinum(II) heteronuclear complexes, [CuPtL(1)(DMSO)Cl(4)] (3) and [CuPtL(2)(DMSO)Cl(4)] (4), were synthesized using two bifunctional ligands, N-[4-(2-pyridylmethoxy)benzyl]-N,N-bis(2-pyridylmethyl)amine (L(1)) and N-[3-(2-pyridylmethoxy)benzyl]-N,N-bis(2-pyridylmethyl)amine (L(2)). These complexes have been characterized by elemental analysis, electrospray ionization mass spectrometry, IR spectroscopy, and UV-vis spectroscopy. The DNA binding ability of these complexes follows an order of 1 < 2 < 3 < 4, as revealed by the results of spectroscopy and agarose gel electrophoresis studies. Their cleavage activity toward supercoiled pUC19 plasmid DNA is prominent at micromolar concentration levels in the presence of ascorbic acid. The introduction of a platinum(II) center to the copper(II) complexes induces a significant enhancement in cleavage activity as compared with copper(II) complexes alone. These results show that the presence of a platinum(II) center in coppe...Continue Reading

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Citations

Oct 10, 2013·Chemical Reviews·Carlo SantiniCristina Marzano
Apr 9, 2013·Journal of Photochemistry and Photobiology. B, Biology·Cansu Gökçe, Ramazan Gup
Jul 21, 2015·European Journal of Medicinal Chemistry·Waseem A WaniLee Ting Hun
Aug 8, 2015·Accounts of Chemical Research·Xiaoyong WangZijian Guo
Apr 29, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Xue-Quan ZhouShi-Ping Yan
Apr 3, 2018·Journal of Biomolecular Structure & Dynamics·Mohd AfzalSartaj Tabassum
May 24, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Rodrigo Castro-RamírezNorah Barba-Behrens
Jan 18, 2012·Chembiochem : a European Journal of Chemical Biology·Kevin E NelsonYi Lu
Jan 17, 2013·The Journal of Physical Chemistry. B·Chunmei LiuMingsheng Tang

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