PMID: 8584081Dec 1, 1995Paper

Prompt gamma ray spectrometry for in vivo measurement of boron-10 concentration in rabbit brain tissue

Neurologia Medico-chirurgica
K MukaiK Matsumoto

Abstract

Boron-10 concentrations in the brain of live rabbits were measured by prompt gamma ray spectrometry at intervals over a 24-hour period. Boron-10 concentrations in the blood and cerebrospinal fluid (CSF) were also measured. Animals were killed at each interval to obtain brain tissues to measure the boron-10 concentration in the brainstem, cerebral cortex, cerebellar cortex, and basal ganglia, as well as the whole brain. Boron-10 concentrations in the live brain did not differ significantly from those measured in whole brain tissue. Boron-10 concentrations in the blood were much higher than in the brain at each interval after injection. These boron-10 concentrations showed a similar pattern of initial rapid decrease, followed by a more gradual decrease. There was little boron-10 present in the CSF. The brainstem contained a significantly larger concentration of boron-10 than the other tissues. Prompt gamma ray spectrometry has the potential for direct measurement of boron-10 concentrations in the brain of patients undergoing boron neutron capture therapy.

Citations

Apr 29, 2008·Critical Reviews in Oncology/hematology·Andrea WittigWolfgang A G Sauerwein
Nov 29, 2017·International Journal of Molecular Sciences·Arthur B VolovetskyAnna V Maslennikova

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