Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effects

Journal of Virology
Ana Virginia CheeBernard Roizman

Abstract

Herpes simplex virus (HSV) 1 disaggregates the nuclear domain 10 (ND10) nuclear structures and disperses its organizing promyelocytic leukemia protein (PML). An earlier report showed that ectopic overexpression of PML precludes the disaggregation of ND10 but has no effect on viral replication. PML has been reported to mediate the effects of interferon (IFN) and viral mutants lacking ICP0 (Delta alpha 0 mutants). To test the hypothesis that HSV disaggregates ND10 structures and disperses PML to preclude IFN-mediated antiviral effects, we tested the accumulation of viral proteins and virus yields from murine PML(+/+) and PML(-/-) cells mock treated or exposed to IFN-alpha, IFN-gamma, or both and infected with the wild-type or Delta alpha 0 mutant virus. We report the following results. (i) The levels of growth of wild-type and mutant viruses and of accumulation of viral proteins were not significantly different in untreated PML(+/+) and PML(-/-) cells. (ii) Major effects of IFN-alpha and -gamma were observed in PML(+/+) cells infected with the Delta alpha 0 mutant virus, and more minor effects were observed in cells infected with the wild-type virus. The effects of the IFNs on either wild-type or the mutant virus in PML(-/-) cell...Continue Reading

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Citations

Mar 4, 2005·Immunogenetics·Thomas RubyRima Zoorob
Jun 14, 2005·Virus Research·S Efstathiou, C M Preston
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Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Maria Kalamvoki, Bernard Roizman
Oct 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Haidong GuBernard Roizman
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