Promyelocytic leukemia zinc finger protein activates GATA4 transcription and mediates cardiac hypertrophic signaling from angiotensin II receptor 2.

PloS One
Ning WangTadashi Inagami

Abstract

Pressure overload and prolonged angiotensin II (Ang II) infusion elicit cardiac hypertrophy in Ang II receptor 1 (AT(1)) null mouse, whereas Ang II receptor 2 (AT(2)) gene deletion abolishes the hypertrophic response. The roles and signals of the cardiac AT(2) receptor still remain unsettled. Promyelocytic leukemia zinc finger protein (PLZF) was shown to bind to the AT(2) receptor and transmit the hypertrophic signal. Using PLZF knockout mice we directed our studies on the function of PLZF concerning the cardiac specific transcription factor GATA4, and GATA4 targets. PLZF knockout and age-matched wild-type (WT) mice were treated with Ang II, infused at a rate of 4.2 ng·kg(-1)·min(-1) for 3 weeks. Ang II elevated systolic blood pressure to comparable levels in PLZF knockout and WT mice (140 mmHg). WT mice developed prominent cardiac hypertrophy and fibrosis after Ang II infusion. In contrast, there was no obvious cardiac hypertrophy or fibrosis in PLZF knockout mice. An AT(2) receptor blocker given to Ang II-infused wild type mice prevented hypertrophy, verifying the role of AT(2) receptor for cardiac hypertrophy. Chromatin immunoprecipitation and electrophoretic mobility shift assay showed that PLZF bound to the GATA4 gene regu...Continue Reading

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Citations

Jan 15, 2014·Current Hypertension Reports·Pawel NamsolleckThomas Unger
Nov 20, 2012·Clinical Science·Ibrahim C Haznedaroglu, Yavuz Beyazit
Aug 8, 2015·Journal of Cardiovascular Pharmacology·Qin LiPeiqing Liu
Jun 7, 2018·Physiological Reviews·Steven J ForresterSatoru Eguchi
Jul 1, 2016·Clinical Science·Bryna S M Chow, Terri J Allen
Jan 18, 2013·Journal of Ophthalmology·Hossein Mostafa ElbadawyStefano Ferrari
Apr 16, 2013·BioMed Research International·Yanli WangEnqi Liu
Mar 12, 2015·Journal of Immunology Research·Marcelo José Barbosa SilvaLiliane Martins dos Santos
Mar 6, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Ivana JukicInes Drenjancevic

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Methods Mentioned

BETA
transfection
two-hybrid
Reverse Transcription Polymerase Chain Reaction
Assay
Immunoprecipitation
ChIP
PCR
transgenic
electrophoretic mobility shift assay
immunoprecipitation assay

Software Mentioned

MatInspector

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