PMID: 11318005Apr 25, 2001Paper

Prone positioning and inhaled nitric oxide: synergistic therapies for acute respiratory distress syndrome

The Journal of Trauma
J A JohannigmanR D Branson

Abstract

Inhaled nitric oxide (INO) and prone positioning have both been advocated as methods to improve oxygenation in patients with acute respiratory distress syndrome (ARDS). This study was designed to evaluate the relative contributions of INO and prone positioning alone and in combination on gas exchange in trauma patients with ARDS. Sixteen patients meeting the consensus definition of ARDS were studied. Patients received mechanical ventilation in the supine position, mechanical ventilation plus INO at 1 part per million in the supine position, mechanical ventilation in the PP, and mechanical ventilation in the prone positioning plus INO at 1 part per million. A stabilization period of 1 hour was allowed at each condition. After stabilization,hemodynamic and gas exchange variables were measured. INO and prone positioning both increased PaO2/FIO2 compared with ventilation in the supine position. PaO2/FIO2 increased by 14% during use of INO, and 10 of 16 patients (62%) responded to INO in the supine position. PaO2/FIO2 increased by 33%, and 14 of 16 patients (87.5%) responded to the prone position. The combination of INO and prone positioning resulted in an improvement in PaO2/FIO2 in 15 of 16 patients(94%), with a mean increase in P...Continue Reading

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Citations

Sep 24, 2002·Pharmacology & Therapeutics·B J Nevin, K J Broadley
Jun 5, 2002·The Journal of Trauma·Andrew J MichaelsWilliam B Long
Oct 30, 2004·The Journal of Trauma·Yoram KleinErik S Barquist
Sep 3, 2002·Current Opinion in Critical Care·Göran Hedenstierna, Marco Lattuada
Oct 5, 2006·Current Opinion in Anaesthesiology·Eleni Mouloudi, Dimitris Georgopoulos
Aug 15, 2014·Expert Review of Respiratory Medicine·Yee Hui MokDavid A Turner
May 17, 2014·Expert Review of Respiratory Medicine·Krishna P AthotaBetty J Tsuei
Jul 12, 2011·Critical Care Clinics·Nitin Puri, Richard Phillip Dellinger
May 1, 2009·Archivos de bronconeumología·Oscar MartínezAndrés Esteban
Feb 10, 2007·Annales Françaises D'anesthèsie Et De Rèanimation·M-S MebazaaM-S Ben Ammar
Nov 7, 2006·Clinics in Chest Medicine·Antonio Anzueto, Kalapatha Guntapalli
Jul 21, 2005·Paediatric Anaesthesia·Giuseppe A Marraro
Sep 11, 2004·Critical Care Nursing Clinics of North America·Kathleen M Vollman
Mar 31, 2005·Nitric Oxide : Biology and Chemistry·Kun HanKi-Wan Oh
Sep 23, 2003·Anesthesia and Analgesia·Jennifer SokolDesmond Bohn
Dec 16, 2010·Journal of Trauma Nursing : the Official Journal of the Society of Trauma Nurses·Jessica R Chadwick
Nov 3, 2021·British Journal of Neurosurgery·Alessandro De CassaiMarina Munari

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