Pronociceptive effects of remifentanil in a mouse model of postsurgical pain: effect of a second surgery

Anesthesiology
David CabañeroMargarita M Puig

Abstract

Remifentanil anesthesia enhances postoperative pain in animals and humans. The authors evaluated the impact of the dose (microg x kg(-1) x min(-1)) and duration of remifentanil infusion, and the effects of a second surgery on postoperative pain sensitization. Mice received different doses of remifentanil over 30 or 60 min. The authors assessed thermal (Hargreaves) and mechanical hyperalgesia (von Frey) at 2, 4, 7, and 10 days. In other experiments, mice had a plantar incision during sevoflurane with or without remifentanil anesthesia that was repeated 27 days later, when nociceptive thresholds returned to baseline. Linear mixed models were used for statistical analysis. Remifentanil induced dose-dependent pronociceptive effects with calculated ED(50)s of 1.7 (95% confidence interval, 1.3-2.1) and 1.26 (1.0-1.6) microg x kg(-1) x min(-1) for thermal and mechanical hyperalgesia, respectively, which lasted longer with higher doses (P < 0.001). The duration of infusion did not alter the pronociceptive effects of remifentanil when administered at a constant dose of infusion. When given during surgery, high (2.66 microg x kg(-1) x min(-1)) or low (0.66 microg x kg(-1) x min(-1)) remifentanil increased the extent (P < 0.05) and durati...Continue Reading

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Citations

Feb 14, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David CabañeroJose A Morón
Aug 11, 2012·British Journal of Anaesthesia·V Martinez, D Fletcher
Oct 10, 2012·British Journal of Anaesthesia·N A ManeringA Tzabazis
Sep 25, 2012·Anesthesia and Analgesia·David Cabañero, Margarita M Puig
Jun 3, 2014·The Journal of Pain : Official Journal of the American Pain Society·Yuan SunJ David Clark
Jun 4, 2013·The Journal of Pain : Official Journal of the American Pain Society·Angela MacalusoSaul Collini
Oct 16, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Philippe RichebéGérard Janvier
Feb 9, 2011·European Journal of Pharmacology·Ana CampilloMargarita María Puig
Mar 20, 2016·British Journal of Anaesthesia·D Fletcher, V Martinez
Oct 21, 2015·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Philippe RichebéVéronique Brulotte
Jul 3, 2015·Journal of Translational Medicine·Anne Gomez-BrouchetVincent Minville
Feb 12, 2013·European Journal of Pharmacology·Asunción RomeroMargarita M Puig
Apr 15, 2011·Korean journal of anesthesiology·Hyong Rae JoYoung Soon Choi
Dec 5, 2014·Korean journal of anesthesiology·Hyeon Jeong Lee, David C Yeomans
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Jun 18, 2017·The Journal of Pain : Official Journal of the American Pain Society·Mauricio Polanco-GarcíaUNKNOWN PAIN-OUT-Spain Consortium
Oct 4, 2016·Laboratory Animals·Daniel Ruiz-PérezIgnacio Alvarez Gómez de Segura
Sep 3, 2013·Current Opinion in Anaesthesiology·Cyril RivatPhilippe Richebé
Apr 2, 2015·American Journal of Therapeutics·Sang Hun KimSergio D Bergese
Jan 25, 2018·The European Journal of Neuroscience·Aizhu LuShiyuan Xu
Mar 10, 2015·European Journal of Anaesthesiology·Avi A Weinbroum
Dec 9, 2014·European Journal of Anaesthesiology·Mariana AbreuIgnacio A Gómez de Segura
Aug 22, 2015·European Journal of Anaesthesiology·Mariana AbreuIgnacio A Gómez de Segura

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