Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone

Proceedings of the National Academy of Sciences of the United States of America
M L WongP W Gold


Both stress-system activation and melancholic depression are characterized by fear, constricted affect, stereotyped thinking, and similar changes in autonomic and neuroendocrine function. Because norepinephrine (NE) and corticotropin-releasing hormone (CRH) can produce these physiological and behavioral changes, we measured the cerebrospinal fluid (CSF) levels each hour for 30 consecutive hours in controls and in patients with melancholic depression. Plasma adrenocorticotropic hormone (ACTH) and cortisol levels were obtained every 30 min. Depressed patients had significantly higher CSF NE and plasma cortisol levels that were increased around the clock. Diurnal variations in CSF NE and plasma cortisol levels were virtually superimposable and positively correlated with each other in both patients and controls. Despite their hypercortisolism, depressed patients had normal levels of plasma ACTH and CSF CRH. However, plasma ACTH and CSF CRH levels in depressed patients were inappropriately high, considering the degree of their hypercortisolism. In contrast to the significant negative correlation between plasma cortisol and CSF CRH levels seen in controls, patients with depression showed no statistical relationship between these para...Continue Reading


Sep 25, 2001·Depression and Anxiety·Martin P. Szuba
Jul 31, 2009·European Archives of Psychiatry and Clinical Neuroscience·George I PapakostasMaurizio Fava
May 13, 2006·Cellular and Molecular Neurobiology·Esther L SabbanRichard Kvetnansky
Dec 21, 2000·Current Psychiatry Reports·S MalhotraK Franco
Mar 25, 2004·Biological Psychiatry·Lisa A Thomas, Michael D De Bellis
May 12, 2005·Neuroscience and Biobehavioral Reviews·Adrian J DunnRenaud de Beaurepaire
Jun 29, 2004·Psychoneuroendocrinology·Joel A PosenerAlan F Schatzberg
May 18, 2005·Psychoneuroendocrinology·Elizabeth A YoungOliver G Cameron
Jun 14, 2005·Psychoneuroendocrinology·I A Antonijevic
Jul 16, 2013·Trends in Pharmacological Sciences·Rita J ValentinoD A Bangasser
Nov 7, 2000·Biological Psychiatry·J KaufmanDennis S Charney
May 23, 2002·Biological Psychiatry·Lucianne GroeninkBerend Olivier
Jan 7, 2004·Biological Psychiatry·E Sherwood BrownBruce S McEwen
Feb 26, 2003·European Journal of Pharmacology·S M Korte, Sietse F De Boer
Jul 20, 2002·Journal of Psychiatric Research·P EikelenboomW van Tilburg
Apr 27, 2001·Neuroscience and Biobehavioral Reviews·S M Korte
Feb 8, 2003·Psychoneuroendocrinology·I A AntonijevicA Steiger
Jun 9, 2001·Trends in Endocrinology and Metabolism : TEM·G CizzaP W Gold
May 2, 2001·Nature Reviews. Neuroscience·M L Wong, J Licinio
Jun 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gareth O MintonSarah E Gartside
Sep 4, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jonathan W StewartDonald F Klein
Apr 2, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Charles Hutchison Keesor WestJay Michael Weiss
Aug 5, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Heath D SchmidtRonald S Duman
May 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nayla N ChaijaleRita J Valentino
Jan 13, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alexander NeumeisterDennis S Charney
Nov 8, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chi-Hua ChenEd Bullmore
Mar 23, 2002·The Pharmacogenomics Journal·J Licinio, M L Wong
Mar 21, 2002·Epilepsia·Ulrich Ebert
May 20, 2003·Neurotoxicity Research·David De Wied, Hein O. Sigling
Feb 26, 2010·Biodemography and Social Biology·David M AlmeidaHeather King


Mar 1, 1978·The Medical Clinics of North America·D T Krieger
Oct 28, 1977·Annals of the New York Academy of Sciences·M F DallmanM H McBride
May 1, 1977·The American Journal of Psychiatry·M G ZieglerI J Kopin
Feb 1, 1976·Psychological Medicine·B J CarrollA A Sugerman
Sep 1, 1988·The Journal of Clinical Investigation·A E CalogeroP W Gold
Dec 1, 1988·Neurosurgery·J N Bruce, E H Oldfield
Aug 11, 1988·The New England Journal of Medicine·P W GoldG P Chrousos
May 1, 1987·The American Journal of Psychiatry·A RoyP W Gold
Nov 1, 1987·Journal of Neurochemistry·D S GoldsteinH R Keiser
Oct 25, 1984·The New England Journal of Medicine·F HolsboerO A Müller
Nov 30, 1994·Annals of the New York Academy of Sciences·K P CorodimasJ Schulkin
Jul 1, 1994·The Journal of Clinical Endocrinology and Metabolism·M A KlingP W Gold
Apr 1, 1994·Neuroendocrinology·M Ehrhart-BornsteinJ J Holst
Feb 1, 1993·Annals of Neurology·S G KalerW A Gahl
Apr 1, 1996·Clinical Endocrinology·M A MagiakouG P Chrousos
Oct 17, 1996·The New England Journal of Medicine·D MichelsonP W Gold
May 7, 1998·Endocrine Reviews·M Ehrhart-BornsteinG P Vinson
Jan 20, 1999·Proceedings of the Association of American Physicians·P W Gold, G P Chrousos
May 14, 1999·The Journal of Clinical Endocrinology and Metabolism·S R Bornstein, G P Chrousos
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

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