Proof of concept study: Improvement of echocardiographic parameters after renal sympathetic denervation in CKD refractory hypertensive patients

International Journal of Cardiology
Márcio Galindo KiuchiJocemir Ronaldo Lugon

Abstract

Evaluation of the effectiveness of the renal sympathetic denervation (RSD) in reducing lesions of target organs such as the heart and kidneys, in resistant hypertensive CKD patients. Forty-five patients were included and treated with an ablation catheter with open irrigated tip. RSD was performed by a single operator following the standard technique. Patients included with CKD were on stages 2 (n=22), 3 (n=16), and 4 (n=7). Data were obtained at baseline and monthly until the 6th month of follow-up. Twenty-six out of the 45 patients had LVH and nineteen did not present LVH. The LV mass index decreased from 123.70±38.44g/m(2) at baseline to 106.50±31.88g/m(2) at the 6th month after RSD, P<0.0001. The end-diastolic left ventricular internal dimension (LVIDd) reduced from 53.02±6.59mm at baseline to 51.11±5.85mm 6months post procedure, P<0.0001. The left ventricular end-diastolic posterior wall thickness (PWTd) showed a reduction from 10.58±1.39mm at baseline to 9.82±1.15mm at the 6th month of follow-up, P<0.0001. The end-diastolic interventricular septum thickness (IVSTd) also decreased from 10.58±1.39mm at baseline to 9.82±1.15mm 6months post procedure, P<0.0001. The left ventricular ejection fraction (LVEF) improved from 58.90±...Continue Reading

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Citations

Aug 22, 2016·International Journal of Cardiology·Márcio Galindo Kiuchi, Shaojie Chen
Oct 6, 2016·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Márcio Galindo KiuchiGladyston Luiz Lima Souto
Mar 8, 2017·The Journal of Clinical Hypertension·Shaojie ChenShaowen Liu
May 31, 2018·Journal of Hypertension·Athanasios KordalisChristodoulos Stefanadis
Nov 22, 2018·Seminars in Dialysis·Neil A HoyeRobert J Walker
Dec 22, 2017·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Márcio Galindo KiuchiHelmut Pürerfellner
Mar 17, 2021·Journal of Cardiovascular Electrophysiology·Gabriela M PradoLuciana V Armaganijan
May 17, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Shin-Huei LiuShih-Ann Chen

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