Prooxidant and antioxidant behaviour of usnic acid from lichens under UVB-light irradiation--studies on human cells

Journal of Photochemistry and Photobiology. B, Biology
Cornelia Kohlhardt-FloehrT George Truscott

Abstract

Natural compounds which can behave as antioxidants and protect against UV-radiation may well have medical and cosmetic value. Usnic acid, which can be obtained from lichens offer such a potential. The latter is one of the best known and reviewed compounds present in lichens and exhibits many properties of value such as antibiotic, antitumor and UV-filter-effects. We report studies of the potential antioxidant and prooxidant activity of usnic acid extracted from Xanthoparmelia farinosa (Vainio) using a human lymphocyte cell line (Jurkat-cells) under UV-B-irradiation. Cell survival and cell metabolism were determined using different conditions such as usnic acid concentration and UVB dose. Compared to the controls the cells incubated with usnic acid in concentrations of 1 x 10(-8) and 1 x 10(-6) M showed a higher cell survival and a normal metabolism under low doses of UVB-light up to 0.1 J/cm(2). When both higher UVB doses (up to 14 J/cm(2)) and higher concentrations of usnic acid (1 x 10(-4) M) where used, the opposite effect was observed. It is concluded that these effects are due to bifunctional (a switch of) anti-oxidative-pro-oxidative behaviour of usnic acid under UV-B-irradiation.

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Citations

May 26, 2012·Phytotherapy Research : PTR·Fabrizia BrisdelliGiuseppe Celenza
Jan 12, 2013·ChemMedChem·Michela BrunoLuisella Verotta
Feb 25, 2015·Natural Product Research·A A S AraújoD P Gelain
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Aug 9, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nayane Moreira MachadoMário Antônio Spanó
Jul 5, 2012·Journal of Agricultural and Food Chemistry·Qian LiuYi Wang
Apr 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mônica Cristina Barroso MartinsNicácio Henrique da Silva
Apr 4, 2017·Journal of the Science of Food and Agriculture·Erik A YeashLew P Christopher
Oct 31, 2013·Natural Product Reports·Khanh-Hung NguyenSophie Tomasi
Nov 7, 2013·Toxicology and Industrial Health·Zühal PolatAli Aslan
Jan 9, 2018·Bulletin of Experimental Biology and Medicine·I A Prokop'evA K Zhanataev
Mar 25, 2017·BioMed Research International·C R SilvaN H Silva
Nov 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ying-Chen ChengHui-Min David Wang
Jul 8, 2021·World Journal of Microbiology & Biotechnology·A ShcherbakovaA Koptina

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