Prooxidant-antioxidant balance in pregnancy: a randomized double-blind placebo-controlled trial of selenium supplementation

Journal of Perinatal Medicine
Fatemeh TaraGordon Ferns

Abstract

We assessed the impact of selenium, a trace element with antioxidant properties on a simple measure of oxidative stress in pregnant women. A novel assay of prooxidant-antioxidant balance (PAB) was applied in a double-blind, placebo-controlled study of selenium supplementation in pregnancy. We measured the prooxidant burden and the antioxidant capacity simultaneously in one assay, thereby calculating a redox index. A total of 166 primigravid pregnant women in the first trimester of pregnancy, were randomized to receive 100 microg of selenium (n=83) or placebo (n=83) per day until delivery. PAB values and serum selenium concentrations were measured at baseline and at the end of study. Pretreatment demographic data and biochemical indices including serum selenium concentrations did not differ significantly between the groups. The drop-out rates for the groups were 22/83 and 19/83 for the selenium and placebo groups, respectively. Supplementation with selenium was associated with a significant increase in mean serum selenium concentration (P<0.001) but without significant change in mean PAB value. In contrast, mean serum selenium concentration remained unchanged and mean PAB values increased significantly (P<0.05 in the control gro...Continue Reading

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Citations

Jan 17, 2012·Applied Biochemistry and Biotechnology·Jing Z DongY Wang
Mar 22, 2012·Applied Biochemistry and Biotechnology·J Z DongY Wang
Oct 23, 2013·Indian Journal of Pediatrics·Hassan BoskabadiGordon A Ferns
Feb 22, 2012·Gynécologie, obstétrique & fertilité·A BenammarR Levy
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Jul 11, 2014·Frontiers in Pharmacology·Emilio A HerreraAnibal J Llanos
Mar 13, 2015·Iranian Red Crescent Medical Journal·Akram MohammadiMajid Ghayour Mobarhan
Jan 5, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Rachael Tindell, Trent Tipple
Jun 14, 2018·International Journal of Environmental Research and Public Health·Jolanta GromadzinskaWojciech Wasowicz

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